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"Hyper" activity as an effect of PD meds


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#1 woodbee

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Posted 20 May 2011 - 02:40 PM

Netgypsy,

You are the only person whom I remember describing "hyper" activity as an effect of your medications. I'm experiencing this from time to time but am not sure if its from the sinemet or the very low dose of requip? I am however fairly certain it is a side effect of my meds.

What is your experience and if anyone else has this I would welcome any thoughts and discussion around this topic.
eileen

#2 Guest_TexasT_*

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Posted 21 May 2011 - 06:28 AM

Eileen,

I have the exact same problem when my Sinemet is at its peek. I am very talkative, full of energy, strong dyskinesias, and my mind races a mile a minute. It is worse with the Teva brand. Not so bad when I took Sinemet made by Mylan.

Tonya

#3 netgypsy

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Posted 21 May 2011 - 12:14 PM

Requip makes me "Sleepy and Dopey", the two dwarfs. It also caused compulsions and a totally reactive personality. Autopilot is the way my family described me. It also caused me to faint 20 or more times a day.

sinemet, on overdose causes mania, feeling very powerful, talking quickly, being argumentative, moving quickly, more dyskinesias, PD symptoms pretty much gone, high energy, taking risks, depending on just how overdosed you are. They say it is very similar to the reaction of people who use cocaine and there are some PWP who deliberately overdose because it is very empowering. I personally don't find it a "high" but I don't know I'm manic unless someone tells me.

You won't normally overdose on regular sinemet but with the added requip, who knows as when I took them together I passed out cold any time I ate with no warning. sinemet CR which works by far the best for me, also will cause overdose as it builds up, so the lit tells you to decrease the dose as the day progresses. I asked the pharmacists on here about dosage and he said every 6 hours for CR was a good starting point. I was taking one 50/200 every 2 hours. I stayed really mobile and functional but my feet moved a lot and I fainted a lot and went manic by the afternoon. I have really good luck with 2 50/200 every 6 hours but this is something you have to experiment with, with your doc.

So chances are it's either the combination or the sinemet. You can take the sinemet down by 1/4 of a tablet and just see.

I forgot to mention, you can get overdose on regular if your stomach doesn't empty and you get a double dose at once when it does. You can tell though because you'll crash for several hours, then go manic. This is stomach emptying problem.

#4 woodbee

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Posted 21 May 2011 - 03:29 PM

Netgypsy, Tonya,
Thanks for the responses. I'm fairly certain I'm experiencing mild mania at peak dose on my sinemet. I talk fast, move fast (Too fast...resulting in minor mishaps, spills, dish breaking, etc...but mostly( a feeling I don't like...as if i'm on the verge of exploding....racing mind, I think) A year ago i was on a higher dose of requip and I have ever so slowly been reducing , reducing. ( i previously experienced DAWS when going off Mirapex 4 years ago so I know to go SLOW. ) I'm down to 4 mg now but seem to have also hit a threshold...go below that and I CAN'T sleep at night.... stay on that dosage, and I have some moderate compulsive behaviors. So I am undecided about which direction to go. The compulsive behaviors are borderline but if they worsen that might be the indicator I need to reduce the requip dosage even more. The requip does help my restless legs syndrome at night....so it's a balancing act I guess.

anyway thanks again for taking time to post a response. It's helpful

Eileen

#5 gazelle66

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Posted 22 May 2011 - 04:37 AM

This is a subject very close to my heart. I recognise many of the symptoms you (and Netgypsy and Tonya) list here. When on Requip 8mg, my personality changed wildly.....I went from a rather introverted, anxious, careful and shy sort of person to one who drove her car dangerously fast, played music at ear splitting volumes, started challanging people but was also much more comfortable around people.

After reading Netgypsys reference to cocain, I wonder if this is why it is so addictive. I am now off of Requip completely, after being diagnosed with a condition called 'hypermania' brought on by 'dopamine overload'.

But for me, being on Requip will always remain the 'best and worst' of times in my life. The worst, because, probably similar to the cocain craving (I don't know, i've never tried it)...the thing you get addicted to, your compulsions, are very strong...you are unable to fight against them and the internal confusion and the price that your family can pay is big. I was horrible to my family. I ignored them in preference to being on the internet. And when they tried to stop me, I was nasty. I would never want to go back to that state again. But on the flip side, I remember being wildly happy....I remember thinking that I could finally for the first time in my adult life be relaxed around people and just feel 'proper' happiness and love for other people...untainted by the bad thoughts and anxieties that usually dogged my days. When I read back over my diary entries from that period, they range from "I have no clue what day, month or year this is" (!!)...to "This is the happiest time of my life...it makes up for all the sh*t of the past..."

You have to be careful of these compulsions, as by their very nature, they are seductive and it took a while for me to admit I needed help to stop. You don't want to stop! I have some overriding memories of the time that will always stay with me...I will share a couple to demonstrate the range of emotions.....

On Christmas day, we had the family round (my husbands family). Despite knowing them for over twenty years, I could still never usually feel relaxed or 'involved' .....we sat in the lounge and played 'Catchphrase'....a guessing game. I remember the feeling of 'belonging'...of feeling loved and being able to love. Being able to talk openly and have a laugh. I will cherish this memory.

On the flip side, I remember many nights sat crying on the phone to the Samaritans (a charity phone service here that allows a person to phone and talk if things are really bad)...the craving I felt...a physical pain in my chest...I couldn't stand it....I was lost and couldn't cope.


I will always miss the confidence and feelings of intense love and happiness that Requip gave me. I'm still recovering I think....as in, my personality change is still in flux....i'm not the person I was pre-Requip. I'm not the person I was on Requip. I'm hoping that some of the real experiences I had at the time have given me a bit more confidence when living my life as it is now.

I can understand why people overdose on levodopa. I would do it myself if I thought it was the answer. But I don't think it is. There has to be a way to achieve peace and happiness surely, without paying the price of these compulsions and the effect they have on your family. Maybe if you have no responsibilities it is a different matter, but I doubt it. For every up side, there is a corresponding down.

Anyway, best wishes as always...
Sue

#6 Guest_TexasT_*

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Posted 22 May 2011 - 07:50 AM

Thank you for sharing what you did, Sue. Sometimes I think I'm lost somewhere in the middle of all that. It's a lonely place to be. No one can help or they don't know how or they just don't want to.
One time, a person suffering from these same problems (or had in the past, but they lingered on even after going off the agonist), told me this, "Nobody understands". That person was right. And, it makes me think it's not just the medicine, it's probably also the PD and what it does to our brains, cognitively and therefore, behaviorly.
What's the answer? To completely go off all PD medication? Maybe. But, would we still have problems with our thinking, feelings, reasoning, etc...? Probably.
Maybe all of us PWP should live in seclusion and with no computer. No? Who knows the answer. All I know is that Parkinson's can be a very mean disease and you can't know these battles unless you have it.

T

Edited by TexasT, 22 May 2011 - 07:52 AM.


#7 Guest_TexasT_*

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Posted 22 May 2011 - 06:21 PM

Wo, did I write that post?
It sounds very negative and I didn't communicate what I wanted to say well.The truth is my head is a little fuzzy right now because I am allergic to my Sinemet. I've been taking the Teva generic for a few months, but had been taking Mylan generic. I'm going from being 'frozen' when 'off' to hyper and my mind racing wile 'on'.
I'll comment again when my head is more clear.
Tonya

#8 netgypsy

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Posted 23 May 2011 - 07:40 AM

I do understand that sinemet can cause compulsions but I don't think it's common but requip and mirapex are famous for all the compulsions they cause so don't think the mania is the same as the compulsions. It isn't.

with the mania you feel empowered and mildly drunk. No compulsions. Just very good and energetic, able to do anything you want to do but you may stagger a bit. I fell once when I was manic and twisted my ankle but I had neuropathy from a B12 and folate deficiency also, so wasn't totally the mania.

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Posted 23 May 2011 - 07:47 AM

I do understand that sinemet can cause compulsions but I don't think it's common but requip and mirapex are famous for all the compulsions they cause so don't think the mania is the same as the compulsions. It isn't.

with the mania you feel empowered and mildly drunk. No compulsions. Just very good and energetic, able to do anything you want to do but you may stagger a bit. I fell once when I was manic and twisted my ankle but I had neuropathy from a B12 and folate deficiency also, so wasn't totally the mania.



Hi netgypsy,

I've been experiencing neuropathy in my hands and forearms the past few months. Did yours go away after taking B12 and folate?

Tonya

#10 gazelle66

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Posted 23 May 2011 - 09:39 AM

I quite liked the mania! I'll stick with sinemet from now on.... :grin:

#11 netgypsy

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Posted 23 May 2011 - 01:36 PM

neuropathy went away. I take 1000 micrograms of each one first daily, then every other day now but I might go back on daily. It was so bad I had NO feeling in my hands or feet. My SO had to feed me. I had no reflexes in my feet. I could barely walk a few feet. It was the pits. One doc said it was the PD but the specialist said it probably wasn't the PD or the PD meds. My GP is the one who found the deficiency.

#12 woodbee

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Posted 23 May 2011 - 01:39 PM

Thanks again everyone for your remarks and discussion...i'm getting a few insights into my own 'stuff'....like n
Netgypsy, I find I must be careful, not to trip or fall or hurt myself when I'm moving fast in that hyper state....feels like I'm one of those old wind-up toys that got round up too tight when first released is out of control. unfortunately for me the rest is true too...eventually the toy functions at normal speed for a while and then great slowing down till we stop again...waiting for the next wind up. Funny metaphor when I think about it but so true.

have good days guys...

Gazelle hope you're on the mend. Tonya...take it easy
netgypsy have a good day




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