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Mirapex and its nasty side effects


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#1 Luthersfaith

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Posted 01 September 2011 - 04:15 AM

I'm off for the holiday and the morning time is free!

I've been on Mirapex for almost 3 months now and I've not experienced any of those nasty side effects yet... I think. Lately I have been suspicious of the idea "maybe I'm going to have a hallucination." Specially when I'm in the dark.

So I was wondering, for those of you who have experience Mirapex, what side effects did you experience?
"I have told you these things, so that in Me you may have [perfect] peace and confidence. In the world you have tribulation and trials and distress and frustration; but be of good cheer [take courage; be confident, certain, undaunted]! For I have overcome the world." - Jesus (John 16:33)

#2 Delta

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Posted 01 September 2011 - 08:17 AM

Insomnia and ironically the abilibity to fall asleep mid-sentence during the day. Nothing else though.

#3 Ken_S

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Posted 01 September 2011 - 06:27 PM

Excessive daytime sleepiness & gambling.
I thought the gambling thing was B.S. until I experienced it.
It was like someone flipped a switch and went away just as fast.

Improvise, Adapt and Overcome


#4 woodbee

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Posted 01 September 2011 - 07:42 PM

I was on it for 6 months only but had nausea, leg swelling, minor visual hallucinations
and when I went off of it (DAWS) dopamine agonist withdrawal symptoms.
eileen

#5 teachn2

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Posted 01 September 2011 - 09:44 PM

Started mirapex 3 1/2 weeks ago. Nausea was awful at first but much better now. No other side affects yet.

#6 CynthiaM

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Posted 01 September 2011 - 11:45 PM

Excessive daytime sleepiness & gambling.
I thought the gambling thing was B.S. until I experienced it.
It was like someone flipped a switch and went away just as fast.


Ken, I am in the process of switching from Mirapex to Sinemet. I started having the compulsive gambling issues too. If I couldn't find someone to make the 2 hour drive to the casino with me, I'd spend hours playing online video poker. When I told my doc about it he said that he was surprised because only 1 in 25 people have that become a problem. It would be my guess that the number is much higher and it's an under-reported problem because it is embarrassing to admit to having problems like that. I also had started having visual and tactile hallucinations. The withdrawals the past 4 or 5 days has been terrible. The worst muscle cramps I've ever had in my life along with terrible anxiety. Hopefully as we increase the Sinemet dose things will get better.
Life isn't about waiting for the storm to pass......It's about learning to dance in the rain.

#7 netgypsy

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Posted 01 September 2011 - 11:49 PM

Since requip is a dopamine agonist and related I'll share my problems for about 6 years at least. Excessive sleepiness, on autopilot, interested in nothing, terrible anxiety, fainted all the time, had compulsions that could have caused me serious problems but I was not in a situation where they were problematic. And the worst thing was, it really didn't have much affect on my PD symptoms even at a high dosage. Caused me to lose three years of my life. Would have gone straight on sinemet if I had it to do over. Even worse anxiety when I came off it. Really debilitating and drove my SO crazy. Interestingly enough sinemet totally killed the anxiety. YAAAYYY.

#8 CynthiaM

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Posted 01 September 2011 - 11:50 PM

I was on it for 6 months only but had nausea, leg swelling, minor visual hallucinations
and when I went off of it (DAWS) dopamine agonist withdrawal symptoms.
eileen


Eileen,
When you went off of Mirapex, how long did it take for you to start feeling better? My head keeps wanting to be pulled down backwards and to the right (my affected side). The muscle in my neck feels like it is constantly tightening, very painful. Never felt anything like this before. Also feel like something is crawling up and down my legs, like a big tarantula. Can't sleep either. I haven't slept more than 3 or 4 hours a night. My anxiety level is off the charts. Was there anything special you did to make the withdrawals easier?
Thanks,
Cynthia
Life isn't about waiting for the storm to pass......It's about learning to dance in the rain.

#9 CynthiaM

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Posted 01 September 2011 - 11:52 PM

Since requip is a dopamine agonist and related I'll share my problems for about 6 years at least. Excessive sleepiness, on autopilot, interested in nothing, terrible anxiety, fainted all the time, had compulsions that could have caused me serious problems but I was not in a situation where they were problematic. And the worst thing was, it really didn't have much affect on my PD symptoms even at a high dosage. Caused me to lose three years of my life. Would have gone straight on sinemet if I had it to do over. Even worse anxiety when I came off it. Really debilitating and drove my SO crazy. Interestingly enough sinemet totally killed the anxiety. YAAAYYY.


That's encouraging! Maybe I will have the same outcome now that I am starting on Sinemet. I increase the dose this coming Tuesday and completely stop the Mirapex.
Life isn't about waiting for the storm to pass......It's about learning to dance in the rain.

#10 woodbee

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Posted 02 September 2011 - 01:52 AM

Cynthia,

when I experienced DAWS I did not know what was happening to me. I thought all my symptoms were being caused by a new medication I was put on for depression. But then I spoke with my doctor and he explained that it was going off the Mirapex that was causing it.. It' s pretty awful. Im sorry you are going through this, It took about a week total for me to get back to a semblance of myself ...pre withdrawal.I did not have the pain in my neck or pulling in my head as you describe but I had symptoms much as you describe and some that were worse. I started feeling some better on or about the 5th day and each day thereafter a little bit better than the previous day. I don't know anything that will help you. I'm sorry. You should let your dr know this is happening to you. Perhaps he/she will have some advice. I'd be interested in learning what he /she tells you but not until after you feel better. I have described what happened to me just a few times on the forum, in the past. Its painful every time but people should be aware that these things happen. Not to everyone but to a few unlucky ones. For me the withdrwal from this medication resulted in the worst days of my life. If I could have died it would have been OK. that is how much I wanted to get away from the symptoms I was experiencing.
Again, let your Dr know this is happening to you if you have not already done so. this is NOT TYPICAL. It happens to a small percentage of people when they go off mirapex . I wish I were there to comfort you and reassure you, wipe your brow and massage your neck but since I can't I will keep you in my thoughts. I hope relief is yours soon, Cynthia.

eileen

#11 Luthersfaith

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Posted 02 September 2011 - 07:07 AM

Wow.
"I have told you these things, so that in Me you may have [perfect] peace and confidence. In the world you have tribulation and trials and distress and frustration; but be of good cheer [take courage; be confident, certain, undaunted]! For I have overcome the world." - Jesus (John 16:33)

#12 MarciaJ

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Posted 02 September 2011 - 10:13 AM

Scary! I hope my neuro puts me straight on Sinemet.

<3.<3.<3.

Age 64 now.  Diagnosed 2006.

Meds-Carbidopa/levodopa 25-100mg cr tabs four times daily
Benztropine 2mg tabs twice daily
B12 tab for memory loss, one daily


#13 woodbee

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Posted 02 September 2011 - 12:04 PM

Yes it is scary,but i did not intend to alarm people. statistically I think the percentage of people who suffer this reaction is low. but if you happen to be one who does, its the craps. Cynthia and I are just unlucky I guess and you may hear more about negative outcomes than positive just because when something works people just move ahead but when it doesn't there's a lot of complaining. thats me. complaining. HA Don't be afraid...just be aware.
HAve good day Marcia

Eileen

Edited by woodbee, 02 September 2011 - 12:05 PM.


#14 km7396

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Posted 02 September 2011 - 04:04 PM

I was on it for about 3 months. I woke up 1 morning and felt that my wife and I should both go and get tattoos then I knew that I was having side affects. I switched to sinemet...I am still tattoo free. ;)

#15 Luthersfaith

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Posted 02 September 2011 - 06:42 PM

I was on it for about 3 months. I woke up 1 morning and felt that my wife and I should both go and get tattoos then I knew that I was having side affects. I switched to sinemet...I am still tattoo free. ;)


WoW... Wooooo... for real?
"I have told you these things, so that in Me you may have [perfect] peace and confidence. In the world you have tribulation and trials and distress and frustration; but be of good cheer [take courage; be confident, certain, undaunted]! For I have overcome the world." - Jesus (John 16:33)

#16 CynthiaM

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Posted 02 September 2011 - 09:19 PM

WoW... Wooooo... for real?


I have no doubt that happened with the tattoo. Last time my husband and I went to Hot Springs to play poker, we drove past some tattoo parlors. I tried to convince my hubby we needed to stop and get a tattoo. I've never had the desire to have a tattoo in all of my 48 years. It wasn't until I read what KM said above that I realized that the whole tattoo thing is just another example of the impulse control issues related to Mirapex.
Life isn't about waiting for the storm to pass......It's about learning to dance in the rain.

#17 xaxa

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Posted 02 September 2011 - 09:26 PM

I luckily had no problems coming off mirapex but went super slow. Like crazy slow. Took over a month to wean myself off of 1mg TID. However, I noticed that I never slept through the night again. Always waking up at least once a night. Coincidence? Hmmmm....

#18 CynthiaM

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Posted 02 September 2011 - 09:27 PM

Cynthia,

when I experienced DAWS I did not know what was happening to me. I thought all my symptoms were being caused by a new medication I was put on for depression. But then I spoke with my doctor and he explained that it was going off the Mirapex that was causing it.. It' s pretty awful. Im sorry you are going through this, It took about a week total for me to get back to a semblance of myself ...pre withdrawal.I did not have the pain in my neck or pulling in my head as you describe but I had symptoms much as you describe and some that were worse. I started feeling some better on or about the 5th day and each day thereafter a little bit better than the previous day. I don't know anything that will help you. I'm sorry. You should let your dr know this is happening to you. Perhaps he/she will have some advice. I'd be interested in learning what he /she tells you but not until after you feel better. I have described what happened to me just a few times on the forum, in the past. Its painful every time but people should be aware that these things happen. Not to everyone but to a few unlucky ones. For me the withdrwal from this medication resulted in the worst days of my life. If I could have died it would have been OK. that is how much I wanted to get away from the symptoms I was experiencing.
Again, let your Dr know this is happening to you if you have not already done so. this is NOT TYPICAL. It happens to a small percentage of people when they go off mirapex . I wish I were there to comfort you and reassure you, wipe your brow and massage your neck but since I can't I will keep you in my thoughts. I hope relief is yours soon, Cynthia.

eileen


Thanks Eileen. I haven't told the doctor yet. I've been trying to tough it out. Mainly because it costs me $160.00 every time I talk to the neurologist. I found out late this afternoon that we've finally met our $10,000 family deductible for the year. The insurance paid all but 16.00 for the last visit I had a little over a week ago. Too bad I found out to late to try and get an appt today. If I'm still having issues when their office reopens on Tuesday I will be sure to call them. In the meantime I'll be using tons of muscle rub. I've found that by putting icy hot on my legs that it even helps with that creepy crawly sensation of gigantic spiders being on me. The thing with the head being pulled back and to the side is a little better today too.
Life isn't about waiting for the storm to pass......It's about learning to dance in the rain.

#19 CynthiaM

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Posted 02 September 2011 - 09:40 PM

Scary! I hope my neuro puts me straight on Sinemet.


So sorry Marcia. Honestly I hope they just start you on the Sinemet too. But really my neuro assured me that the kind of problems I had with it is pretty unusual. When I first started taking it I felt like it was a wonder drug. It made me be able to do things that I had not been able to do in years. I'm sure there are lots of people that take Mirapex and don't have any problems with it. I'm just glad that you are going to try and start a medication. It will give you your life back. I waited way too long to push the doctors into figuring out what was wrong with me.
Life isn't about waiting for the storm to pass......It's about learning to dance in the rain.

#20 woodbee

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Posted 03 September 2011 - 12:56 AM

For another side effect of mirapex read the thread on dr okun's forum called mirapex and paranoia. It's down on the list about the 21st thread written around Aug. 30.

Amazing ! What a nightmare!




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