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Post of the Week: Bladder Dysfunction and Parkinson's Treatment


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#1 Dr. Okun

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Posted 23 October 2011 - 02:54 PM

Dear forum members,

Bladder issues can emerge in PD. These have recently been reviewed by the authors below. A common complaint is urgency (need to go to the bathroom) and a common treatment is anticholinergics. The problem as the authors point out is that anticholinergics cab lead to confusion and side effects. More research is needed in this area, as many PD patients complain of these issues.

Neurobiol Dis. 2011 Oct 10. [Epub ahead of print]
Pathophysiology of bladder dysfunction in Parkinson's disease.
Sakakibara R, Tateno F, Kishi M, Tsuyuzaki Y, Uchiyama T, Yamamoto T.
Source
Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
Abstract
Bladder dysfunction (urinary urgency/frequency) is a common non-motor disorder in Parkinson's disease (PD). In contrast to motor disorders, bladder dysfunction is sometimes non-responsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine basal ganglia-frontal circuit, which normally suppresses the micturition reflex. The pathophysiology of the bladder dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. These treatments might be beneficial in maximizing the patients' quality of life.

Copyright © 2011. Published by Elsevier Inc.

PMID: 22015601 [PubMed - as supplied by publisher]

Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips


#2 mickie

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Posted 22 November 2011 - 07:37 AM

My bladder problem simulates that of interstitial cystitis. The urologist did a cystoscope and found no bladder problem and no bacteria infection accompanies the episodes. I am a 67 year old woman diagnosed just this year with PD but have had 3 of these episodes in the last 4 years, one lasting 7 months. Is this a PD problem or indicative of something else?
May each day bring joy!

#3 Dr. Okun

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Posted 22 November 2011 - 12:38 PM

Not sure based on the data you provided, however in many cases mysterious bladder function issues are related to PD.

Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips





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