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Post of the Week: Surfing the PD Pipeline for New Therapies


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#1 Dr. Okun

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Posted 15 November 2011 - 07:32 AM

Dear forum members,

Dr. Robert Hauser has recently penned an outstanding paper reviewing all the new therapies in the Parkinson's disease pipeline. Dr. Hauser is professor at the NPF Center of Excellence at the University of South Florida in Tampa.

Here is the link to the article which is free access through pubmed: http://www.ncbi.nlm....pubmed/22035030


Int J Neurosci. 2011;121 Suppl 2:53-62.
Future Treatments for Parkinson's Disease: Surfing the PD Pipeline.
Hauser RA.
Source
Departments of Neurology, Molecular Pharmacology and Physiology, College of Medicine , University of South Florida, Tampa, Florida USA.
Abstract
ABSTRACT Our current wish list for the treatment of Parkinson's disease (PD) includes therapies that will provide robust and sustained antiparkinsonian benefit through the day, ameliorate or prevent dyskinesia, and slow or prevent the progression of the disease. In this article, I review selected new therapies in clinical development for motor features or treatment complications of PD, and some that may slow disease progression. These include adenosine 2a (A2a) antagonists (istradefylline, preladenant, and SYN115), levodopa/carbidopa intestinal gel (LCIG), IPX066-an extended-release formulation of carbidopa/levodopa, XP21279-a sustained-release levodopa prodrug, ND0611-a carbidopa subcutaneous patch, safinamide-a mixed mechanism of action medication that may provide both MAO-B and glutamate inhibition, PMY50028-an oral neurotrophic factor inducer, antidyskinesia medications (AFQ056 and fipamezole), and gene therapies (AAV2-neurturin and glutamic acid decarboxylase gene transfer). Some of these therapies will never be proven efficacious and will not come to market while others may play a key role in the future treatment of PD.

PMID: 22035030 [PubMed - in process]
LinkOut - more resources

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Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

#2 FredericB

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Posted 15 November 2011 - 10:52 AM

For people interested by a hierarchical view of the pipeline, we maintain a curated tree of the different trials we are aware of at http://www.pearltree...9&N-f=1_3142359

#3 Dr. Okun

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Posted 17 November 2011 - 07:21 AM

Thank you for your link. Your site is very organized and interesting!
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips




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