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Post of the Week: Ho Amantadine Went from a flu drug to a Parkinson's drug

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#1 Dr. Okun

Dr. Okun

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Posted 08 April 2012 - 07:52 PM

Dear forum members,

UF Med student Grant Hubsher recently published an article describing how a single observation in a patient with Parkinson's disease taking amantadine for flu, led to the use of amantadine in Parkinson's disease. His paper appears in this month's edition of Neurology. This is a really interesting story. The abstract is below:

Neurology. 2012 Apr 3;78(14):1096-9.
Amantadine: The journey from fighting flu to treating Parkinson disease.

Hubsher G, Haider M, Okun MS.

Correspondence & reprint requests to Dr. Okun: okun@neurology.ufl.edu.



To explore how amantadine transitioned from an anti-flu drug to antiparkinsonian agent.


A review of the historical literature on the use of amantadine from 1966 to the present was performed.


Amantadine was originally introduced and utilized as an antiviral medication. A single patient noticed relief in her Parkinsondisease (PD) symptoms after taking amantadine for a flu infection, and this observation sparked an interest, and several important studies that eventually led to a new drug indication.


Amantadine has over the years fallen out of favor as a drug to address influenza infection; however, it has become part of the arsenal utilized for early symptomatic treatment of PD, as well an option for treating dyskinesia.



[PubMed - in process]

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Michael S. Okun, M.D.

Author of Amazon Kindle, Paperback and Audio of 10 Breakthrough Therapies for Parkinson's Disease
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

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