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Sinemet CR vs. Stalevo


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#1 miracleseeker

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Posted 04 December 2012 - 11:40 PM

Dr. Okun,

What's the difference? Will CR last just as long as Stalevo?

#2 Dr. Okun

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Posted 05 December 2012 - 03:27 PM

Different mixes of drugs. Sinemet CR is an extended release drug and in general does not last much longer than regular sinemet and some experts do not use it at all. Stalevo is regular sinemet plus COMTAN. the comtan component will make the sinemet last a little longer in some patients but will also raise the blood level of dopamine and could precipitate dyskinesia in some cases.
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

#3 miracleseeker

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Posted 05 December 2012 - 05:11 PM

Do you see anything wrong with taking Sinemet in place of Stalevo for one of the doses of the day if the patient takes Stalevo 3 times a day ordinarily? This way there will be less comtan in the body and still get the long lasting effects of Stalevo for the day.

Do you think mixing the 2 drugs although not taken at the same time is dangerous or will put the body into shock since technically they are not the same medication?

#4 Dr. Okun

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Posted 05 December 2012 - 07:35 PM

Its not dangerous, but a lot of times mixing and matching without the docs help can set you back. It is more common to add a little plain sinemet in some cases to Stalevo. There is however an art to this and you and your doc may discover something that works for you.
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips




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