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#1 Jenette


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Posted 26 January 2013 - 02:20 PM

I have been struggling for a few weeks now with never feeling well. I'm assuming its what is called being "off."

My neurologist switched me from. Mirapex .5 twice a day to Mirapex ER 1.5 once a day. This is in addition to Sinemet 25/100 four times per day. I feel fine far bait, but most times I feel like I have to poop,even when I know I don't. Is this part of the "off" feeling? It's debilitating.

#2 christie


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Posted 26 January 2013 - 03:42 PM

Hi Jenette. Have you discussed this with your neurologist? Muscle contractions in the rectal area or a feeling of incomplete evacuation may be caused by anal sphincter dysfunction (dystonia of the sphincter muscle) and respond to levodopa. BTW, do you have constipation? any pain at bowel movements? abdominal pain or any blood in stools? make sure this is PD-related (sounds like it is, but you could also consult a gastroenterologist).

Edited by christie, 26 January 2013 - 03:43 PM.

-English is not my first language !

-Aged 39. Diagnosed at 35.

-Currently on madopar (levodopa and benserazide, 500mg daily) and Azilect (1mg daily).

#3 Jenette


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Posted 26 January 2013 - 05:48 PM

Thanks! I notice that if I take my Sinemet closer together it gets better

#4 MarciaJ


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Posted 26 January 2013 - 07:10 PM

I had been on generic mirapex which totally wiped me out. It was like the flu. I spent most of the day on the couch. The neuro changed my meds and much better.



I had treatment for cancer in 2003-2004.


Symptoms started shortly before Diagnosed 2006. At Age 54 .


Waited 5 years before it was necessary to start meds. 

Meds-Carbidopa/levodopa 25-100mg cr tabs four times daily
Benztropine 2mg tabs twice daily
B12 tab for memory loss, one daily


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