Urate vs. Low Protein Diet
Posted 04 April 2013 - 01:26 PM
Posted 06 April 2013 - 04:23 PM
First, you may not need to change your diet at all. And, second, I would not change it until you have used levodopa for at least a few weeks.
Initially, some folks experience nausea when starting levodopa, and should take it with meals to help control this. Gradually, the body adjusts to this, usually in 2-4 weeks. At this point if you are responding well to levodopa, there is no need to make any dietary change at all.
However, some people are more protein-sensitive -- especially in later stages of PD. Proteins are broken down in the small intestine to their various amino acid components, and these aminos have special "carries" in the intestinal walls that allow them to cross over into the bloodstream. Some of the amino acids in protein foods compete with levodopa for absorption.
In some people, the small intestine moves more slowly, and the large amount of amino acids blocks the levodopa from entering the bloodstream. When this happens, PD symptoms are not well controlled.
If you find that this should be the case, then if nausea is no longer (or never was) a problem, begin taking the levodopa about 30 minutes before meals, which will allow the levodopa to enter the bloodstream ahead of the protein in your meal.
You may well be correct that the serum urate from the high protein diet has slowed progression of your PD; there is considerable interest among researchers on this topic, although the results are suggestive, rather than definitive. In any case, I would continue your current eating plan -- there may be no need whatever to change it. Let me know if I can answer further questions.
Kathrynne Holden, MS
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Posted 07 April 2013 - 08:19 AM
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