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creatine supplements for PD


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#1 johnnys

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Posted 07 April 2013 - 09:03 PM

Parkinson's disease is caused by the degeneration of dopaminergic neurons of substantia nigra
projecting to striatum. Persons with Parkinson disease (PD) exhibit decreased muscular fitness
including decreased muscle mass, muscle strength, bioenergetic capabilities and increased
fatigability. [7]

The causes for Parkinson's disease or neural-degeneration are probably related to
mitochondrial malfunction, elevated oxidative stress, apoptosis, excitotoxicity, and inflammation.
[1,3] Levodopa is a popular treatment for Parkinson's disease, but this treatment is effective for
only a few years. [1] Other treatments newly developed or under development include methyl- and
ethyl-esterified forms of L-dopa (etilevodopa and melevodopa), Glial cell line-derived
Nuerotrophic Factor (GDNF), inhibitors of enzymes such as monoamine oxidase type-B
(monoamine oxidase inhibition, eg, rasagiline, safinamide), catechol-O-methyl transferase (eg,
BIA-3202), the monoamine re-uptake mechanism (eg, brasofensine), full or partial dopamine
agonists (eg, rotigotine , sumanirole, piribedil and BP-897). [1-3]

Non-dopaminergic treatments include alpha2 adrenergic receptor antagonists (eg, fipamezole),
adenosine A2A receptor antagonists (eg, istradefylline), AMPA receptor antagonists (eg,
talampanel), neuronal synchronization modulators (eg, levetiracetam) and agents that interact
with serotonergic systems such as 5-hydroxytryptamine (5-HT)1A agonists (eg, sarizotan) and
5-HT2A antagonists (eg, quetiapine). [1-3]

Neuroprotective agents include anti-apoptotic kinase inhibitors (eg, CEP-1347), modulators of
mitochondrial function (eg, coenzyme Q10, creatine), growth factors (eg, leteprinim),
neuroimmunophilins (eg, V-10367), estrogens (eg, MITO-4509), c-synuclein oligomerization
inhibitors (eg, PAN-408), anti-inflammatory agent and sonic hedgehog ligands. [1-3]

Does gene therapy benefit patients suffered from Parkinson's Disease?
Three genes that produce dopamine were inserted into a disabled equine virus that was then
injected into the brain. Six human volunteers began clinical trials a year ago, and the results are
"extremely encouraging," as measured in control of Parkinson's symptoms and in side effects
such as brain inflammation. In a study of acaque monkeys, ProSavin, the gene therapy restored
the monkeys' levels of dopamine, corrected motor problems and prevented dyskinesias, as
jerkiness, rigidity and tremor.

Does Coenzyme Q(10) benefit Patients with Parkinson's Disease?

Coenzyme Q(10) is a key component of the mitochondrial electron transport chain (ETC). It
serves as the electron acceptor for complexes I and II in the electron transport chain; it is also an
antioxidant. In Parkinson's disease, researchers found deficiency of complex I activity and
increased numbers of activated microglia in both Parkinson's disease postmortem tissue.
Researchers also found decreased levels of coenzyme Q(10) in blood and platelet mitochondria
from Parkinson's disease patients. Thus, impaired mitochondrial function and activated
microglia may both contribute to oxidative damage in Parkinson's disease. In a phase II study,
coenzyme Q(10) appeared to slow the progression of Parkinson's disease. [4]

Can non-steroidal anti-inflammatory drugs (NSAIDs) benefits patients with Parkinson's
disease?

Researchers found activated microglia and increased levels of inflammatory mediators in the
striatum of deceased Parkinson's disease patients. Perhaps not surprisingly, some studies have
shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduced the risk of developing
Parkinson's disease. [5]

Does creatine benefit people suffered from Parkinson's disease?

Mitochondrial dysfunction plays a major role in the pathogenesis of Parkinson disease (PD).
Creatine (Cr) is an ergogenic compound that exerts neuroprotective effects in animal studies.
Researchers from University of Munich, Germany conducted a 2-year placebo-controlled
randomized clinical trial on the effect of Cr in 60 patients with Parkinson disease. Creatine
improved patient mood and led to a smaller dose increase of dopaminergic therapy but had no
effect on overall Unified Parkinson's Disease Rating Scale scores or dopamine transporter
SPECT. [6]

Researchers from Columbia University found that creatine supplementation can enhance the
benefits of resistance training, such as Chair rise performance, in patients with Parkinson
disease. [7] Creatine is well-tolerated in most studies. However, intake of creatine does have
side effects. The common side effects of creatine are upper respiratory symptoms, joint pain,
and nausea. [8]

More about Parkinson's Disease
Parkinson's Disease - Supplements
Parkinson's Disease - Herbs
Parkinson's Disease - Side Effects of Drugs
Parkinson's Disease - Symptoms

[1] Fernandez-Espejo E. Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies. Mol Neurobiol.
2004 Feb;29(1):15-30. [2] Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004
Jul;5(7):720-6. [3] Bonuccelli U, Del Dotto P. New pharmacologic horizons in the treatment of Parkinson disease. Neurology. 2006 Oct
10;67(7 Suppl 2):S30-8. [4] Beal MF. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann N Y Acad Sci. 2003
Jun;991:120-31. [5] Shults CW. Therapeutic role of coenzyme Q(10) in Parkinson's disease. Pharmacol Ther. 2005 Jul;107(1):120-30.
Epub 2005 Apr 21. [5] Hald A, Lotharius J. Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Exp
Neurol. 2005 Jun;193(2):279-90. [6] Bender A, et al, Creatine supplementation in Parkinson disease: a placebo-controlled randomized
pilot trial. Neurology. 2006 Oct 10;67(7):1262-4. [7] Hass CJ, et al, Resistance training with creatine monohydrate improves upper-body
strength in patients with Parkinson disease: a randomized trial. Neurorehabil Neural Repair. 2007 Mar-Apr;21(2):107-15. [8] NINDS
NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease.
Neurology. 2006 Mar 14;66(5):664-71. Epub 2006 Feb 15. [9] Gene therapy for Parkinson's "encouraging" in early trials AFP Wed Oct 14,
11:07 AM PDT


#2 nels02

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Posted 18 April 2013 - 01:45 PM

It really takes a lot of mental gymnastics to read your post, but we need that kind of exercise. So, thanks. I have been part of the large creatine trial for almost five years. I don't know if I am taking creatine or a placebo, but determining actionable outcomes in a study like this seems next to impossible to me. Bottom line, if it only appears to the smallest degree that creatine remotely may provide a neuro-protective benefit, I would take it.

#3 johnnys

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Posted 03 June 2013 - 08:49 AM

Hi,
I've been taking creatine for awhile now and it's helped alot.My stamina has returned and I don't get the ups and downs like before from the sinemet .I also don't get the cramps as much.Sleep has improved quite a bit.Hope all this continues.Im stilll taking 3 25/100 sinemet generic
best to all of you.

#4 johnnys

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Posted 21 June 2013 - 09:32 PM

lately i have been suffering from bad shoulder.the tendon is calcived and irrated.part of it might be caused by the creatine as it's noted to case joint problems so be wary.another cause might be stooped posture that causes shoulder problems.mine is not to bad but sometimes im realy bent over.This shoulder pain in the worst ive ever had and my shoulder is good only if i reach back.hope it gets better for the summer.our bodies realy take a beating with this disease.

#5 Rogerstar1

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Posted 21 June 2013 - 09:42 PM

Sounds like it might be distonia - IMO the worst of the worst PD symptoms. With luck it could be L-dopa responsive as my elbow variety was for awhile. It might be arthritis and treatable by cortisone injection if you are really lucky. Keep us posted, please.

#6 johnnys

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Posted 22 June 2013 - 08:11 AM

hi,
i had a cortisone shot.the office i went to spent very little time explanning anything.the doc finaly came in and walked around the small room and left maybe 2 min. of his time.went to another office yesterday and this doc explanned the whole problem.she showed me the xray and explained about how this can seem to come out of nowhere.my shoulder has been weak for awhile before thisbut little pain.she said therapy and time should take care of it.
i to thought for awhile it might be dystonia but my sinemet had no effect on it.muscle wasting from parkinson im sure doesnt help much.thanks for all of your concerns

#7 Brad24

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Posted 01 July 2013 - 12:04 AM

Johnnys, I have gone to a great PT. She gave me some good shoulder exercises. If you want I can explain them to you in a private message. Don't wanna bore others.

Thanks
Brad
DETERMINATION "In the heart of the strong shines a relentless ray of resolve...It cannot be stopped, it cannot be controlled, and it will not fail."




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