Jump to content


E-Newsletter Signup Like us on Facebook Sign Up For Our e-Newsletter
Photo

Conflicting research on melatonin

melatonin light therapy

  • Please log in to reply
3 replies to this topic

#1 rappleman

rappleman

    Newbie

  • Members
  • Pip
  • 6 posts

Posted 29 April 2013 - 07:16 PM

Research literature suggests both that melatonin is bad for PD (melatonin antagonists eg light therapy may be useful):
https://www.ncbi.nlm...pubmed/17516492
http://www.ncbi.nlm....ubmed/19145986/
http://www.ncbi.nlm....pubmed/22499678
http://www.ncbi.nlm....pubmed/17612949

and also that melatonin is good for PD (melatonin supplementation may be a useful therapy):
http://www.ncbi.nlm....pubmed/22010042
https://www.ncbi.nlm...les/PMC3187674/
http://www.bioportfo...-Phenotype.html

Obviously this is all still early research with very small test patient numbers, but could you please take a stab at explaining for the layman and the implications if any, especially if one or the other approaches might do harm?

Thanks!

#2 Dr. Okun

Dr. Okun

    Advanced Member

  • Ask the Doctor Moderators
  • PipPipPip
  • 4,739 posts
  • LocationUniversity of Florida

Posted 30 April 2013 - 02:53 PM

There is not much available to make this determination for melatonin in PD and we need larger and better powered studies. In my own patients I have not found it to be very useful, but it has not been harmful to anyone in our practice. Some patients note mild benefits. I will post so others can comment.
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

#3 jas1125

jas1125

    Member

  • Members
  • PipPip
  • 20 posts

Posted 21 May 2013 - 02:57 PM

I've been trying a bit less than 1MG for my mother, who has PD for 13 years now. Her sleep is disrupted at night when given a bridge does of Sinemet at 3AM so that she isn't as stiff and rigid when she gets up in the morning. So far, so good as to the melatonin although she has said she is having more vivid dreams, which I know is a side effect. She does seem more rested but I'm hesitant to have her take this on a regular basis

#4 Dr. Okun

Dr. Okun

    Advanced Member

  • Ask the Doctor Moderators
  • PipPipPip
  • 4,739 posts
  • LocationUniversity of Florida

Posted 21 May 2013 - 07:48 PM

Keep us and her docs posted!
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users