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Timing of meds (Sinemet and Mirapex)

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#1 bjenczyk


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Posted 18 July 2013 - 07:29 AM

I am currently taking Sinemet 25/250 3 times a day, and Mirapex .5 mg 3 times a day. Is there any advantage or disadvantage to taking them together, versus taking them an hour or so apart? I had been taking them together at 3:00 AM, 9:00 AM and 3:00 PM, but now I am taking the Sinemet on that schedule and the Mirapex at 4:00, 10:00 and 4:00. I'm curious if it matters.

Thanks in advance.

Dx'd 3/12 @ 48. Symptoms 7 years prior.
carbidopa/l dopa 25/250 6x daily, CR 2 pills at bedtime
No DaT scan, normal MRI. Dx'd by observation of neurologist,

Symptoms: left side rigidity when "off", sleep disruption, no sense of smell, minor fatigue, back pain


Still an optimist - what is wrong with me?

#2 MComes RPH

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Posted 31 July 2013 - 03:41 AM

The advantage of taking the sinemet am hour before the Mirapex, is that the Sinemet is stopping any "off" periods you may be experiencing.
My medication is exactly like that. My one medication (which is sinemet CR, where yours os Mirapex), was only lasting until 2pm instead of 3pm. So, instead of changing my whole sleep schedule, we just added sinemet 25/100 at 2pm, and that took care of the CR wearing off. So now I just take a 25/100 tab 1 hour before my CR (in your case, Mirapex), and it was all fixed.
Hope that helped, keep me posted.
Best of health,
Mark R. Comes R.Ph.
Board Certified Pharmacist,
Medical Board Member, & Consultant.
National Parkinson Foundation
"Ask The Pharmacist"

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