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URSODIOL - A Potential New Drug for PD

Drug Treatments

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1134 replies to this topic

#1121 AB-Normal

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Posted 06 January 2016 - 03:16 PM

Grunt? you could not have said it better..........  I agree he does sounds like a Huckster/snake oil salesman.... Personally? I'll take the knowledge and opinion of Christy, a trained physician, over some huckster with zero medical training at all. Especially some huckster on the internet........... In my opinion, WE should ALL be calling the 1-800-4PD-INFO number and vocally complaining about this thread, and the antics of it's promoters....... because it one were to have followed it from the beginning, there have been several things that could be considered illegal, such as offers to buy and distribute this URDODIOL to various members............

 

So yes, I'll stand with you, patriot, Christy and others, in the belief that this whole thread needs to go away............


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Michael
Current age= 56
First symptoms: 1975
Dx.
Parkinson's Disease, Apraxia
Med's
Carba/levodopa 25/100 ER 4 times a day
Amantadine 100mgs twice a day

DBS surgery 12/2014............ Bilateral lead placement with a single battery/stimulator on RH side. Turned on 12/21/14

"I will do what i can, while I can, and when i can't, I'll do something else"
remember folks.................
KEEP CALM, and PARKIE ON...............

#1122 MrFritz

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Posted 09 January 2016 - 06:33 PM

What a bunch of crap.
If you take this drug you can not only stop taking all your other PD drugs but, you will also be able to walk 1/2 a mile.
I feel like I have been listening to a snake oil salesman....

Rick

 

Yes Rick. You are 1000% correct. It is a bunch of crap with a capital "C." And. snake oil is not the only thing that they are selling. BTW, the "they" is Christie et al.

 

Jon, Rick Copple, Hans55 and all of the others, myself included, who have posted their experience here have tried UDCA/TUDCA and found it to be beneficial. All of us are still using it. I have been a user for over 2 years. Rick and Jon for over 1 year.

 

This forum thread is meant to be read by people interested in alternative treatments. If you are not interested, then don't bother to read or post. If you are interested, then read what PWP who have tried UDCA/TUDCA and posted here have to say (exclude me if you wish). There are a significant number of us. Rick Copple's posts and especially his personal blog is a fascinating read. His story started a year ago. You can read his blog at http://rickspdjourne...experiment.html (read from the bottom up) or, you can just ask him by posting in this thread. I'm sure he will reply to you as will most of the others.

 

The word is spreading. Treatments for PD containing UDCA and/or TUDCA are starting to appear. I continually receive e-mails from PWP all over the world. Many are currently using UDCA/TUDCA successfully and, as expected, there are some for whom it did not work. Check out the new supplement "Restore" at www.WeHaveParkinsons.com and while you are there, click on the blue "*REVIEWS" tab on the left center side to see what a few of their users had to say. Restore's ingredients contain TUDCA. BTW, I have no affiliation or financial interest with any web site(s) and/or product(s). I have been fully retired from all business interests since 2009.

 

Only Christie (a doctor of questionable repute) and a couple of other miscreant who have NEVER tried UDCA/TUDCA have been constantly misinforming readers such as yourself by deliberately spouting outrageous lies, half truths and innuendos. Obviously, their agenda is to try to prevent you and others from trying anything that is not a "standard" approved treatment for PD.

 

Here is the bottom line about UDCA/TUDCA for people with PD who can read and comprehend the English language:

  • UDCA/TUDCA is NOT a cure for PD or any other neurodegenerative disease.
  • UDCA/TUDCA does NOT replace any of your currently prescribed PD medications.
  • We believe and hope that UDCA/TUDCA MAY slow or stop PD's progression. This is unprovable at this time.
  • Nobody has reported any side effects other than headaches, rash or minor gastro issues which cease when usage is stopped.
  • We DO recommend consulting with your doctor before starting this regimen.
  • We DO recommend following our guidelines if you want to try UDCA/TUDCA.
  • We DO NOT recommend self-experimentation with your prescribed medications.

Fred


72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.


#1123 metacognito

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Posted 10 January 2016 - 09:15 AM

What a bunch of crap.
If you take this drug you can not only stop taking all your other PD drugs but, you will also be able to walk 1/2 a mile.
I feel like I have been listening to a snake oil salesman. I find it hard to believe that you went from being DX with PD to finding your magic bullet cure all in what 18 months! Then you try and convince others to follow your led. Take this new drug for PD and you to can stop all your other drugs. I get tremors so bad at times my glass of milk turns to butter but I'd rather have butter then to take drug advice from someone on an open forum. I can't believe at 73 years old you would be as irresponsible as I believe you to be. People with PD (especially those newly DX) are looking for help and answers when they come to this web site the last thing they need is to find and read this thread and start questioning there Doctor before they even get thier meds adjusted.
I think it's time to let this thread die. Just my opinion.

Rick

 

A "bunch of crap"? Either you haven't read the associated studies on the matter or you're simply not able to process the info described therein. And, I think bear-bile salesman might be more accurate than "snake oil salesman" - except that, after a couple hours of reading through the postings here, I don't get the impression 'MrFritz' is doing anything but simply reporting - from his personal experience - about the perceived benefits of a compound that's been extracted from the gall bladders of unsuspecting Asian bears for centuries. Since then in fact, synthesized version/s of T/UDCA have emerged as increasingly promising treatments for various maladies including, most importantly, neurodegenerative diseases such as ours:

 

PubMed abstract (Aug2015) excerpts: "The bile acids tauroursodeoxycholic acid(TUDCA) and ursodeoxycholic acid (UDCA) have been recently shown to be neuroprotective in other protein misfolding disease models, including Parkinson’s, Huntington’s and Alzheimer’s diseases, and also in humans with amyotrophic lateral sclerosis... Treatment targets have included inhibition of protein accumulation,clearance of toxic aggregates, and prevention of downstream neurodegeneration. No one target may be sufficient; rather, compounds which have a multimodal mechanism, acting on different targets, would be ideal. TUDCA and UDCA are bile acids that may fulfill this dual role.. Importantly, these are natural compounds which are orally bioavailable, permeable to the blood-brain barrier, and U.S.Food and Drug Administration-approved for use in humans" http://www.ncbi.nlm....pubmed/25972546

 

PubMed abstract (May2014) excerpt/s: "There is a growing body of research on the mechanism(s) of TUDCA and its potential therapeutic effect on a wide variety of non-liver diseases. Both UDCA and TUDCA are potent inhibitors of apoptosis, in part by interfering with the upstream mitochondrial pathway of cell death, inhibiting oxygen-radical production, reducing endoplasmic reticulum (ER) stress, and stabilizing the unfolded protein response (UPR). Several studies have demonstrated that TUDCA serves as an anti-apoptotic [restorative/neurogenetic] agent for a number of neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease... A growing number of pre-clinical and clinical studies underscore the potential benefit of this simple, naturally occurring bile acid, which has been used in Chinese medicine for more than 3000 years." http://www.ncbi.nlm....pubmed/24891994

 

None of the PubMed reports, and none of what I've read from 'MrFritz' impresses me as someone selling "snake oil". I personally find the information shared rather interesting and well-intended (and if I didn't I'd just move on to the next forum). The only "selling" I detect here is that of an overly pedantic "doctor" with FAR too much time on her hands, a pathetic 'clinger' who basically agrees with/or echos everything the doctor(?) says, and a few low-info, drive-by shooters - all trying to sell themselves as intellectuals. Otherwise, I enjoy the thread.


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#1124 MrFritz

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Posted 10 January 2016 - 11:35 AM

Kudos to metacognito for an excellent reply. You condensed the facts and cited the most relevant studies. I also loved your descriptor of Christie as "an overly pedantic "doctor" with FAR too much time on her hands."  An excellent descriptor.

 

Christie is proud to tell you that she did/does peer review for PubMed. I shudder to think about how many beneficial studies she may have quashed based less on the science but more on her overly opinionated thinking. During her 2 year rant in this thread, she has yet to cite a single study or article supporting any of her points which include: 1) UDCA/TUDCA is harmful and 2) Neither UDCA nor TUDCA is of benefit for PWP.

 

As you may have noticed, I did not bother to reply to Christie's last post because it was purposely written to entice an argumentative reply rather than a discussion of the merits of UDCA/TUDC. The two most important and overlooked relevant facts are:

  • Other posters here have tried UDCA/TUDCA and corroborated what I have said about it.
  • No poster who tried UDCA/TUDCA reported any serious and/or lasting side effects.

They say you can lead a horse to water but you can't make it drink. Well, I've led many to these waters. I've cited the evidence (clinical studies) that its long and short term usage won't harm you and that it is neuroprotective. I've told you how it benefited me. Others have tried it and corroborated my findings. I can not do anything more. The ball is in your court. G_d helps those that help themselves. [ Don't you just love idioms?  :razz:  ]

 

Fred


72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.


#1125 Research Fiend

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Posted 06 March 2016 - 04:06 PM

This thread and Fred's efforts in it have been amazingly useful for my husband since he was diagnosed two years ago. He cannot find a doctor open-minded enough to prescribe UDCA, but we are buying TUDCA from powdercity.com, and my husband's symptoms have rolled back about five years. Most dramatically, his quality of sleep has improved. He used to be thrashing around and yelling every night, and that is gone. His falls have also decreased from one every few weeks to one every six months. (Tremors have yet to be much of a problem.)

 

I will never understand the nasty, accusatory hysteria of "Christie" (who refuses to provide an actual name or specific credentials, and whose "credentials" sound completely fictional to me) and company, people who have never and will never try something terrifically helpful to a number of people here. It's not enough that they not take it, they need to threaten those who are being helped. All I can say is good luck with your mental illness, it seems quite advanced.

 

Some people need to mindlessly follow all authority figures, and others do their own research. As a researcher type, I don't care what the close-minded do for treatment. It is incredibly weird how fixated the authority freaks are on the treatment of my husband and others who have used TUDCA and UDCA.

 

Thank you, Fred and others who have spoken up!


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#1126 musicman

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Posted 06 March 2016 - 04:39 PM

..just when I think this forum has gotten a little bit boring, voila....


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Bob

 

Diagnosed July of 2014 (age 57) by MDS and a DatScan. 

Began Azilect 8/6/2014

Started Sinemet 10/25/14.

 

https://www.youtube.com/acoustisongs

 

 


#1127 MrFritz

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Posted 17 April 2016 - 03:33 PM

Greetings and Salutations

 

It has been a while since I posted here. My DW has not been well and I've had some non-PD related issues of my own to deal with.

Firstly, I was not getting any forum e-mails for the past month or two. According to the Forum Admin, "
Your email address was removed from your Forum user account.  We remove email addresses whenever we receive alerts that emails have failed.  I have re-entered your email address.  You should start receiving your email alerts again.
" So if anyone had tried to contact me using the forum's messaging service, I would not have received it. Remember, you can always PM me at mrfritz@comcast.net

I read Research Fiend's posting about her DH's improvement since starting TUDCA. I cannot express just how good it makes me feel reading these stories. Thank you for taking the time to post your results.

I want to take a moment to restate that when it comes to PD symptom reduction, UDCA/TUDCA does not work for everyone. For those for whom it does work, each person's results may differ. The more advanced your disease is, the less likely you are to see any benefit. However, the one big unknown is with PD's progression. We believe that it does slow progression and nothing in my personal experience or that of other posters leads me to believe otherwise. So, it is possible that UDCA/TUDCA may not reduce your symptoms but it may still slow its progression. There is just no known way to tell.

Finally, after having been on 1200mg of Ursodiol (UDCA) for 2½ years, let me update you on my condition which, for the most part, has improved:

 

  • I do seem to have a little more sporadic dominate right hand tremor when holding or carrying a glass, eating with a fork or mixing something. Nothing bad. Just a little disconcerting.

 

  • Most notable is my RBD (Rapid eye movement sleep Behavior Disorder). I still occasionally thrash about and yell. But it is no longer an everyday occurrence. It’s been months since I last recall fighting or hitting anyone or anything.

 

  • I had been, for the most part, housebound due to Nocturia with extreme urgency caused by a grossly enlarged prostate compounded by my PD. I was waking up every 45 minutes and had to run fast. After being on UDCA, my symtoms improved to where I was waking up every 2 hours or so. 11 years ago I had a green laser procedure which worked wonders for me. However, my Urologist told me that I am now contraindicated for this procedure because of my PD. As always, I did my research and found that todays thinking has changed. I provided my Urologist with the studies and he agreed to do the procedure. Today (6 months later) I am good for 2-4 hours during the day (if I don't over-indulge on coffee), I sleep through the night and I do not have any leakage issues. I no longer plan my excursions around bathroom locations. Life is now greatly improved to the point of being almost normal.

 

Well, that’s all I have to say for the moment. Hope to hear from you soon.

 

Fred


Edited by MrFritz, 17 April 2016 - 03:37 PM.

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72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.


#1128 MrFritz

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Posted 23 June 2016 - 08:36 PM

NEWS  YOU  SHOULD  HAVE  HEARD HERE BUT DIDN’T

 

Sorry for not posting sooner. My DW is back in the hospital again so my mind is elsewhere and my time more limited. I expect her to be home tomorrow or by Monday at the latest.

 

Recently, I have seen newbies posting in the forum as well as asking questions in Ask the Doctor. Today, one of the Ask the Doctor questions relates to the subject on this post. So for the newbies, do your homework and consider getting on the this bandwagon. For many, it’s a much better ride then the path you’re currently on.

 

As I noted some time ago, after having stopped all of my PD meds for 1 month while remaining on UDCA, my pre-UDCA tremors returned albeit at a significantly lower intensity. Now after 2½ years on the same prescription dosage + UDCA with zero change in symptoms, I have recently noted an increase in my body tremor when tired or stressed and a tremor in my dominate right hand when walking while holding something or performing a repetitive motion. These tremors annoy me greatly although they are neither bad nor constant. I had hoped that the UDCA would stop the progression of my PD.

 

As I have said before, I do not recommend self-experimentation. However, I am willing to experiment on myself provided that what I do is safe for me. Currently I take 1200mg of UDCA per day (4 doses of 300mg). So I tried a 9 day regimen of 2400mg per day. I think I felt a very slight improvement. But this may have just been wishful thinking. Anyway, the difference (if any) was not significant enough. So, I reverted back to my normal dosage of 1200mg per day.

 

In a recent e-mail conversation with Jon (jds6958), he referred me to recent article entitle “Natural molecule NAC could benefit patients with Parkinson's disease.”

I read the article and found it interesting. Here are some links.:

It happened that a year ago I had tried taking NAC and a few other supplements along with my PD meds and UDCA. At that time, I did not notice any difference at all. So I stopped taking the supplements. This time, I started taking 2400mg of NAC in 4 doses. Although it did not relieve my new tremors, I did notice enough of a reduction to indicate that it is doing something positive. This prompted me to pass this on to you.

 

I will now continue to take NAC. Not so much to relieve or ease symptoms but primarily in a further effort to slow the progression of my PD. I don’t recommend brand name products. However, the brand of NAC I’m using is NOW’s brand of NAC which is available in 600mg capsules. My current recommendation is to take 1200mg [T]UDCA plus 2400mg NAC daily in addition to your currently prescribed drugs.

 

Fred


72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.


#1129 Waywrd1

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Posted 24 June 2016 - 06:26 PM

All I can say is that I've been prescribed plenty of off label use drugs over the years.



#1130 PENNYBUTLER

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Posted 04 July 2016 - 06:51 PM

Fred, When I told my MDS that I am taking NAC, he told me to keep taking it. There is a clinical trial underway to test if it slows progression. I am currently taking the NOW brand as well. I take 3000 mg a day. Not sure if it is slowing progression, but zero side effects. I pray it's working.
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#1131 MrFritz

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Posted 05 July 2016 - 12:54 PM

Hi Penny. Thanks for posting.

 

Unlike PD symptoms, there is no way for us PWP's to ascertain any change in progression. So, we do for ourselves what we think may help without causing us any harm.

 

Just like I did with Ursodiol / [T]UDCA, I read what research was available and made a decision. Considering my condition way back then, it was the best decision I ever made. Had I done otherwise, I think that by now I’d be looking at having a DBS implant.

 

As for how much NAC one should take, I don’t have a clue and I don’t think anyone really does. It was Jon who recommended that I take 2400mg/day which is what I had tried some time ago with other additional supplements.

 

Are you or have you tried [T]UDCA? If so, what were your results?

 

Fred


72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.


#1132 PENNYBUTLER

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Posted 05 July 2016 - 02:08 PM

I haven't tried either one.

#1133 MrFritz

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Posted 16 July 2016 - 03:56 PM

I just received a PM from Steve to which I am replying publicly in case others have interest.

Steve asked: “Its been awhile since your last post, and I was wondering how the ursodiol is working?”

 

The most useful answer is as follows:

 

When I first started taking Ursodiol (UDCA), it eliminated almost all of my PD symptoms including tremors. I hoped that it would also stem any further progression. Numerous others have tried both UDCA and TUDCA with similar but varying results. Everybody is different.  For a small minority, it did not work at all. Nobody reported any negative experience other than minor stomach issues which ceased upon stopping. Some have posted their experiences in this thread.

 

My unscientific analyses of our combined experiences bring me to the following conclusions:

  • [T]UDCA does not replace your currently prescribed medications.
  • [T]UDCA works to reduce symptoms for a significant percentage of PWP.
  • The sooner one starts after being dx’ed, the greater the benefit gained.
  • PWP who are more advanced may see little if any benefit.
  • We believe that [T]UDCA slows progression but this cannot be established or measured by us.
  • If you stop [T]UDCA, all prior symptoms will return full-force.

 

Originally, in addition to other tremors and symptoms, I had a minor body (torso) tremor most notable at night or when physically/mentally stressed as well as a tremor in my dominate right hand when holding a glass while walking or performing a repetitive motion. Now, 2½ years after I started UDCA, these two tremors have returned but to a significantly lessor degree. Thankfully, none of my other symptoms have returned. The bottom line is that UDCA is still working for me and I will continue taking UDCA into the foreseeable future.

 

If it works for you, [T]UDCA benefit is almost immediate and lasting. As for the other supplements, I am taking 2400mg/day of NAC and had previously tried other supplements. But I cannot say for sure if they are worthwhile. If you have any questions, please feel free to post or PM me.

 

Regards,

Fred


Edited by MrFritz, 16 July 2016 - 03:58 PM.

72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.


#1134 MarcB

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Posted 17 July 2016 - 03:15 PM

I spend a lot of time researching PD, to include reading all the PD forums and I find this thread very disheartening.  I have no doubt that everyone on here is of good faith and have the other’s best interest at heart, but some have gone off the rails re how they treat those with whom they disagree.

 

The primary reason anyone reads health forums is to find out what other people are doing that works for them that is not evidence based, that the FDA has not approved, and is off label -- because the FDA has approved so precious little for PWP, we don’t need forums for that.  

 

There is a small group who feel one should not do anything that isn’t evidence based and that one should only do what their doctor agrees with.

 

When I post comments on PD forums, I don’t use the word “should.”  I don’t know what is best for others.  I only post what I do and why.

 

By advocating for URDODIOL, MrFritz is not controlling anyone’s decisions, but if his detractors were to succeed in getting this thread blocked, they would be controlling other people’s decisions.  When you control what one person writes, you control what another person reads and, therefore, what they think. 

 

That all posts should be backed up by evidence, in my opinion, might needlessly allow one’s condition to worsen.  Let me use as an example a drug that has not been discussed on this thread, why only evidenced bases therapies should be used is a disservice to PWP.

 

Isradipine is an old, not very good drug recognized by the FDA in 1990 as safe and effective for hypertension in.  Isradipine is completing 3 years of phase III clinical trials in 57 locations in Canada and US to see if it slows the progression of PD.  That means hundreds of PD neurologists, MDs, molecular biologists, and executives of universities, governments, and PD foundations have decided to spend tens of millions of dollars betting that Irasdipine will be recognized by the FDA as safe and effective in slowing Parkinson’s.  Since the trial is not yet complete, it is not “evidence,” but its place in the process is good enough for me to take it now – because the FDA approval is many years away and the difference between slowing my progression now instead of 5 years from will change my life.

 

I learned about Isradipine on another PD forum.  If some people were to succeed in locking or removing threads from forums, I would never have learned about this and therefore would have been deprived on making my own decisions as to what is best for me. I’m taking Isradipine, but I have hypertension.  I would take even if I didn’t have hypertension.  However, I don’t have an opinion as to whether others should take it or not take it.  Others can do their own research, make and be responsible for their own decisions.  

 

Another example of compounds that may be beneficial and may not ever be evidenced based to the degree drugs are, are supplements.

 

One of the other PD forums I monitor is an international forum where many of the leading participants are molecular biologists and other health care researchers and scientists, neurologists, and MDs, etc. They share research data, personal experiences and have in-depth discussions re meds and supplements.

 

Supplements are not subject to FDA approval and get a small fraction of the research as do manufactured drugs, but there is no question that some supplements benefit some people.

 

Some of the more common supplements discussed on PD forums are;

 

N-acetyl cysteine (NAC)

Trans-Resveratrol

Curcumin

Chlorophyllin

Artichoke extract

Grape Seed extract

Broccoli extract

Green Tea extract

Quercetin

B Vitamin Complex, C, D, and E

Magnesium

I3C (Indole-3-carbinol)

Milk Thistle extract

Probiotics Complex with Acidophilis

Melatonin

 

I’ve done research on these and I take some of them.  I take all supplement content with a big helping of salt because a lot of the supplement content are websites selling supplements, there are no government regulations as to quality or purity and often few competent clinical trials.  I do not have an opinion as to whether anyone else take or not take supplements.

 

To research these, Google, for example, “trans-resveratrol Parkinson’s forums.”

 

A Parkinson’s blogger I like is Frank Church.  A medical school and undergraduate biology educator, biomedical science researcher and part-time golfer.  “My diagnosis of Parkinson's disease, combined with my career in science and education, allows me the ultimate "teachable moment". Thus, the theme of this blog is my journey with Parkinson's.”

 

https://journeywithp...rankchurch2015/

 

His protocol;

 

https://journeywithp...m-and-exercise/

 

Contrary to my assertion that I don’t give advice, I have some, albeit non-medical.

 

If you have PD, and want to be less anxious, live longer, be healthier, and happier, quit watching so much TV, especially cable news, become a courteous driver, quit drinking, exercise a lot, especially vigorous bicycle pedaling, eat right (perhaps the Mediterranean diet) and volunteer to enrich the lives of those less fortunate.

 

My post here today is meant only as food for thought.

 

I wish you all the very best on your journey with Parkinson’s.


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#1135 MrFritz

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Posted 22 July 2016 - 05:02 PM

I just came across this abstract. The full article is not available yet. Very interesting. There may yet be hope yet for PWP.

 

Fred

 

==========

 

Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.

Zhang L1, Yin JC1, Yeh H1, Ma NX1, Lee G1, Chen XA2, Wang Y2, Lin L3, Chen L3, Jin P3, Wu GY4, Chen G5.

 

Author information

 

1Department of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.

2Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

3Department of Human Genetics, Emory University School of Medicine, Whitehead Research Building, Room 323, 615 Michael Street, Atlanta, GA 30322, USA.

4Department of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA; School of Life Science, South China Normal University,    Guangzhou 510631, China. Electronic address: gangyiwu1@gmail.com.

5Department of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: gongchen@psu.edu.

 

Abstract

 

We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequential exposure of human astrocytes to a cocktail of nine small molecules that inhibit glial but activate neuronal signaling pathways can successfully reprogram astrocytes into neurons in 8-10 days. This chemical reprogramming is mediated through epigenetic regulation and involves transcriptional activation of NEUROD1 and NEUROGENIN2. The human astrocyte-converted neurons can survive for >5 months in culture and form functional synaptic networks with synchronous burst activities. The chemically reprogrammed human neurons can also survive for >1 month in the mouse brain in vivo and integrate into local circuits. Our study opens a new avenue using chemical compounds to reprogram reactive glial cells into functional neurons.

 

Copyright © 2015 Elsevier Inc. All rights reserved.


72 years old; dx'ed 2012; 1000mg Vitamin D3; 100mg LOSARTAN + 5 mg AMLODIPINE for High Blood Pressure; 6 tabs 25/100 CARBIDOPA/LEVODOPA + 1 mg RASAGILINE for PD + Started UDCA (Ursodiol) on October 16, 2013. Currently on 300mg 4x/day for a total of 1200mg. Started NAC on June 18, 2016. Currently on 600mg 4x/day for a total of 2400mg.





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