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L Dopa: can use of LDopa increase progression?


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#1 New normal

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Posted 10 March 2014 - 10:14 AM

I am hesitant to use L Dopa/Carbidopa in fear it may increase progression of PD or I may become resistant to its benefits. I am 66 yr old female. Dx'd 6 mos ago. Have significant tremor full rt side. If I take prescribed doseage of 250/50 mg 4x daily, I am symptom free. However, I try to take less, and tolerate tremor activity, because I think I am prolonging effectiveness of the drug over the long span of the disease. Is there any research that the drug loses effect over time, and I shd try to save it for when I am in most need?
Dx'd 6/13 @ 66 by MDS in office with sub linquil L dopa challenge. Carbidopa/l dopa 50/200 5x in 24 hr span.
Reaction to Amantadine 100 mg 2x per day,Discontinued, 4/15.
Normal DaT scan '13, normal MRI, '13 Second DaT scan, 10/14, normal.
Symptoms: 90% controlled: significant tremors rt & lft side, rt leg drag whn tired, balance, slow movement, cognitive/ speech issues, apathy, full body dystonia seizures approx one per day, dysfunctional autonomic systems
Cherish your loved ones, make memories with them..........now.

#2 Dr. Okun

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Posted 10 March 2014 - 12:39 PM

I have a nice What's Hot column about levodopa not accelerating disease progression or being toxic in Parkinson's disease.  In general you want to take what you need to control the symptoms and the dose will vary patient to patient.


Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

#3 New normal

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Posted 10 March 2014 - 10:33 PM

I appreciate your timely response. I now feel comfortable taking the prescribed dosage. My quality of life will be significantly improved. Your time expended on behalf of PWP is of great worth. Thank you.
Dx'd 6/13 @ 66 by MDS in office with sub linquil L dopa challenge. Carbidopa/l dopa 50/200 5x in 24 hr span.
Reaction to Amantadine 100 mg 2x per day,Discontinued, 4/15.
Normal DaT scan '13, normal MRI, '13 Second DaT scan, 10/14, normal.
Symptoms: 90% controlled: significant tremors rt & lft side, rt leg drag whn tired, balance, slow movement, cognitive/ speech issues, apathy, full body dystonia seizures approx one per day, dysfunctional autonomic systems
Cherish your loved ones, make memories with them..........now.

#4 Dr. Okun

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Posted 11 March 2014 - 06:01 AM

Thank you.


Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips




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