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L Dopa: can use of LDopa increase progression?


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#1 New normal

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Posted 10 March 2014 - 10:14 AM

I am hesitant to use L Dopa/Carbidopa in fear it may increase progression of PD or I may become resistant to its benefits. I am 66 yr old female. Dx'd 6 mos ago. Have significant tremor full rt side. If I take prescribed doseage of 250/50 mg 4x daily, I am symptom free. However, I try to take less, and tolerate tremor activity, because I think I am prolonging effectiveness of the drug over the long span of the disease. Is there any research that the drug loses effect over time, and I shd try to save it for when I am in most need?
Dx'd 6/13 @ 66. Symptoms 10 years prior.
carbidopa/l dopa 50/200 5x daily
Normal DaT scan '13, normal MRI, '13 Dx'd w/l dopa challenge in office by MDS
Second DaT scan, 10/14, normal.
Symptoms: tremors rt & lft side, rt leg drag whn tired, balance, cognitive/ speech issues, apathy
Live, laugh, and be happy.

#2 Dr. Okun

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Posted 10 March 2014 - 12:39 PM

I have a nice What's Hot column about levodopa not accelerating disease progression or being toxic in Parkinson's disease.  In general you want to take what you need to control the symptoms and the dose will vary patient to patient.


Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

#3 New normal

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Posted 10 March 2014 - 10:33 PM

I appreciate your timely response. I now feel comfortable taking the prescribed dosage. My quality of life will be significantly improved. Your time expended on behalf of PWP is of great worth. Thank you.
Dx'd 6/13 @ 66. Symptoms 10 years prior.
carbidopa/l dopa 50/200 5x daily
Normal DaT scan '13, normal MRI, '13 Dx'd w/l dopa challenge in office by MDS
Second DaT scan, 10/14, normal.
Symptoms: tremors rt & lft side, rt leg drag whn tired, balance, cognitive/ speech issues, apathy
Live, laugh, and be happy.

#4 Dr. Okun

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Posted 11 March 2014 - 06:01 AM

Thank you.


Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips




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