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23andME PD Genetic Research


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#21 she-ra

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Posted 21 December 2012 - 08:49 AM

I have partial results but could sure use some help understanding what they mean.

Sheila ^_^

 

Current age= 61

Symptom Onset- 2009 (56)

 

Current meds:Sinemet 3X/day (25/100) 


#22 she-ra

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Posted 03 January 2013 - 08:15 AM

Still no response from my email request from 23andMe for clarification but I have been reviewing the results with a little more clarity. If I am understanding correctly, it says I have a decreased risk for PD ("slightly lower odds of developing PD, between 1 and 0.67 times typical odds/risk.) I don't know what to do with this information but will certainly share this with the Dr. next visit. The other results are interesting, so far nothing earth shattering. I guess I was under the delusion that this test would either exclude you or include for PD.

Sheila ^_^

 

Current age= 61

Symptom Onset- 2009 (56)

 

Current meds:Sinemet 3X/day (25/100) 


#23 Kristakj78

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Posted 20 February 2013 - 05:13 PM

Can a blood test determine parkinsons disease?
Can a blood test determine if you have parkinsons disease. im scared!


No, but bloodwork can determine if you carry one of the mutated PD genes. Even if you do, it doesn't always mean you will develop PD. I had my bloodwork drawn two months ago (mid December), and just got my genetic results back last week. Turns out I do have a variant on the LRRK2 gene. I have a PD dx, and am young, so they did the bloodwork on me to find out more.

#24 cberns

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Posted 12 March 2013 - 09:47 AM

OK, so I received my results back from 23andMe. They don't say whether or not I have the variant of the LRRK2 gene. They just say which genes are high risk and low risk for me for mutation. Anyone have the same issue? The report does state that I am at typical risk for PD and that it is 73% probable that it is environmentally related.

Any feedback would be awesome.

#25 Daven

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Posted 16 July 2013 - 08:15 AM

I received my results from 23andMe today. According to the results I have slightly higher odds of developing PD on the "Parkinson's Disease: Preliminary Research" section of the report. However, under the "Parkinson's Disease" section, I have a 1.3% chance of developing PD. That's less than the average with someone of my ethnicity. My odds of developing PD based on my genetics is low. I think I should play the lottery tonight. Maybe I'll get lucky again.

Dave

#26 she-ra

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Posted 16 July 2013 - 12:32 PM

So glad you pointed out that section! I either overlooked it or did not understand what I was seeing. I am at slightly lower odds for Parkinson's and moderately increased odds of essential tremor! I will definitely share this with my neurologist next time. Guess I will buy a lotto ticket too.

Sheila ^_^

 

Current age= 61

Symptom Onset- 2009 (56)

 

Current meds:Sinemet 3X/day (25/100) 


#27 Island Woman

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Posted 16 July 2013 - 12:59 PM

I received my test kit in March...any know if it's still good and can I still send it in?

Patricia

#28 tlstarkenberg

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Posted 20 April 2014 - 09:52 PM

4/20/14

Got my free spit bottle and an invitation to take a million survey's (something I try to avoid). I spat spit in my bottle . I've got 50 percent of the surveying done, and the wait is on for the DNA results. Let you know what percentage I fall in.



#29 Beau's Mom

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Posted 21 April 2014 - 10:40 AM

Hi tlstarkenberg,

 

I did that over two years ago. I fell in the unlikely to get PD class, but found hundreds of 3rd to 6th cousins all around the world who wanted to know my genetic history!

 

Dianne


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I am not a human being trying to have a spiritual experience; I am a spiritual being having a (sometimes difficult) human experience.


#30 she-ra

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Posted 21 April 2014 - 02:24 PM

I also fell into the unlikely class and found cousins I never heard of.  Mom knew of a few and said not to make contact!!! Too funny! 


Sheila ^_^

 

Current age= 61

Symptom Onset- 2009 (56)

 

Current meds:Sinemet 3X/day (25/100) 


#31 Janet Tennent

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Posted 02 December 2014 - 09:06 PM

I would love to be able to take this test through 23andme but I live in the state of Maryland and they will not allow people to take this test. I have thought about having it sent to a friends house in another state. I did do a DNA test through FamilyTreeDNA but it does not check for medical markers.


Janet

Diagnosed age 59, Azilect 10/14


#32 Linda Garren

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Posted 03 December 2014 - 05:32 PM

Got the kit in the mail the other day...right now not sure if I really want to know what other future problems could be bouncing around in my body...have to give it some thought.

 

LOL!  I understand, and I have the same concern.  :-)  I don't think I could take one more diagnosis of anything!

 

Nice to  see you posting, Patricia.


Age 67.  Retired from Johns Hopkins University and Medical Institutions after 36 years in a number of administrative coordination positions within the various institutions.

Diagnosed with PD summer 2014. 

 

 

 

 

 


#33 ShopGuy

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Posted 11 January 2015 - 02:08 PM

Received my results from 23andMe last week. For what it's worth, apparently the FDA has asked them to stop providing the 'health assessment,' so only ancestry information and a searchable database of raw genetic information are reported now. No risk of hearing bad news you're not ready for.

 

I found a nonprofit Wikipedia-style website that lets people search what the raw genetic information might mean: http://www.snpedia.c...dex.php/SNPedia . It's pretty good, with links to published research. There's even a page specific to Parkinson's genetics: http://www.snpedia.com/index.php/Parkinson%27s_disease .

 

With a little cutting and pasting, you can use the SNPedia site and the raw data from 23andMe to check risk for Parkinson's and other conditions. For example, I found I have no increased PD risk from LRRK2 mutations, but did find the version I have of a SNP called Rs9652490 carries 2X Parkinson's risk.

 

SNPedia also provides a service called Promethease http://www.snpedia.c...php/Promethease that uses 23andMe data to create a health assessment report similar to what 23andMe used to provide. Not sure if I'm ready to explore that yet, for the same reasons mentioned by others up thread.  



#34 Janet Tennent

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Posted 12 January 2015 - 11:11 PM

I tried clicking on the link that allows you to take the test for $25. but it no longer works. Shop Guy when did you order your test? Was it through the link that provides the test for $25? I took a DNA test through Family Tree Finder with the intent to find cousins unknown to me. Most of the people I contacted said they don't see a relationship in their tree compared to my tree. I think my connection to these "new" cousins is an unknown ancestor they have not found.


Janet

Diagnosed age 59, Azilect 10/14


#35 ShopGuy

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Posted 13 January 2015 - 08:14 PM

Hi Janet,

Here's the link I used: https://www.23andme.com/pd/

Click on the "Join Today--I have Parkinson's" tab. Should be a completely free test for people diagnosed with PD. My test arrived early December, and I had my results a bit sooner than the 4-6 weeks they say it takes.

--David


Edited by ShopGuy, 13 January 2015 - 08:15 PM.


#36 Janet Tennent

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Posted 16 January 2015 - 09:42 PM

Shop Guy,

Thank you. Just went there and registered. I am not sure they will send the test to me as I live in Maryland. 23andMe does not allow Maryland residents to purchase a test kit. It has something to do with Hippa laws and state laws. Maybe because I have been diagnosed with Parkinson's they will make an exception. I will post here if I receive the kit.


Janet

Diagnosed age 59, Azilect 10/14


#37 TexasTom

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Posted 17 January 2015 - 08:03 AM

It's interesting.  What is funny is I hated Brussel Sprouts as a kid.  Could not stand them, but rest of the family loved them.  These days I love them (lightly roasted, with garlic,yum)

 

fully heterozygous, age related tasting variation You are heterozygous at all 3 of the SNPs which are known to influence the ability to taste bitterness. This means you are better than average at detecting bitter tastes while young, but that this ability will decrease to less than average during adulthood. As a child you will probably hate brussel sprouts, and by early adulthood will discover that olives and brussel sprouts now taste good. A 2010 study shows the change bitter sensitivity which occurs over the lifespan (from bitter sensitive to less so) is more common in people with this genoset. Children with this genotype could perceive a bitter taste at lower PROP concentrations than could heterozygous adults. The threshold for adolescents was intermediate. The 3 SNPs are rs10246939, rs1726866, rs713598 in the gene TAS2R38.

 

more likely to be able to smell asparagus metabolites in urine 1.67x more likely than people with (G;G) to be able to smell the methanethiol produced after eating asparagus.

 

Intermediate riser. Wakes up at a time between the AA and GG genotypes.

 

Fast Caffeine Metabolizer. Unlike the majority of people, caffeine is broken down faster in your liver, so it has less effect on you. Supposedly this decreases heart attack risk, although other studies show caffeine is generally good for the heart. Caffeine will be less effective at preventing Breast Cancer, Alzheimer's Disease, and Parkinson's disease. Caffeine will not make your breasts smaller. 

 

Parkinson's -- increased risk.   For anyone wondering.... typically it is 1 in 1000.  So even with the genetic, being 2x normal population it means 1 in 500.   So for those reading the genetic reports, take it with a large does of salt. 

 

Only one that seems interesting, for medical, is 4x likely to have Hemochromatosis.  Condition of too much iron in my blood.  Irony is I'm always good when donating blood as my numbers are always good, so that is something being checked every 8 weeks.  


Dx 9/2014   56 years old  

Sinemet  1&1/2  -- 25/100  3x daily. 

 

 

Beautiful young people are accidents of nature, But beautiful old people are works of art. Learn from the mistakes of others. You can't live long enough to make them all yourself.   -- Eleanor Roosevelt


#38 Janet Tennent

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Posted 24 January 2015 - 09:32 PM

I received my answer from 23&me that because I live in Maryland I am not allowed to take the genetic test. I don't know now if I use somebody's address outside of Maryland if they will send me the test.


Janet

Diagnosed age 59, Azilect 10/14





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