Jump to content


E-Newsletter Signup Like us on Facebook Sign Up For Our e-Newsletter
Photo

New Study: A New Target for the Treatment of Dyskinesia


  • Please log in to reply
2 replies to this topic

#1 Dr. Okun

Dr. Okun

    Advanced Member

  • Ask the Doctor Moderators
  • PipPipPip
  • 4,824 posts
  • LocationUniversity of Florida

Posted 07 August 2009 - 04:18 PM

This researcher from NYU has been working on a new potential drug target for the treatment of Dyskinesia

Sci Signal. 2009 Jul 21;2(80):pe42. Links
Thwarting dyskinesia by targeting mTORC1.

Klann E.
Center for Neural Science, New York University, New York, NY 10003, USA. eklann@cns.nyu.edu
In a mouse model of Parkinson's disease, new evidence shows that l-DOPA, which is used to treat the symptoms of the disease but also causes dyskinesia, results in a persistent activation of the protein kinase mTOR (mammalian target of rapamycin) in a subset of striatal medium spiny neurons. Moreover, blockade of a specific type of mTOR signaling (mTORC1) prevents the development of dyskinesia, but not the antiakinetic benefits produced by l-DOPA. Thus, mTORC1 may be a viable therapeutic target for dyskinesia caused by l-DOPA treatment in patients with Parkinson's disease.
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

#2 Guest__*

Guest__*
  • Guests

Posted 08 November 2009 - 08:13 PM

Seriously interesting.

#3 Dr. Okun

Dr. Okun

    Advanced Member

  • Ask the Doctor Moderators
  • PipPipPip
  • 4,824 posts
  • LocationUniversity of Florida

Posted 11 November 2009 - 08:34 AM

Thanks for the comment.
Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users