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how long does it take for Sinemet to relieve symptoms?


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#1 Guest__*

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Posted 02 March 2010 - 04:51 PM

How long does it take for Sinemet to relieve symptoms of PD if it proves to be effective at all? I've taken it for 10 days.

#2 Dr. Okun

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Posted 03 March 2010 - 07:55 PM

Be careful as it may be that the dose is inadequate, the interval is inadequate, the diagnosis is off, or you have a lot of non-motor symptoms that do not respond to sinemet.

I usually work with my patients by getting a baseline scale called the UPDRS and then increasing dose and/or decreasing frequency---I then recheck the scale and also address non-motor symptoms.

It usually shows effects within a week.

Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips


#3 Guest__*

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Posted 07 March 2010 - 01:47 PM

For some patients, it takes longer. When first diagnosed, I was told to start with 1/2 sinemet (25/100) per day, then go to 1 per day after a week, then 1 1/2 per day after another week, and so on, until I reached 4 per day. I felt absolutely no effect until 2 1/2 per day (which happened after a month). Even then, I did not have very good control of my symptoms until I went to six pills per day, over a year later.

I wrote about this at http://forum.parkins...opic.php?t=4885

#4 Dr. Okun

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Posted 07 March 2010 - 08:21 PM

Thanks for the post. You are right. Therapy must be tailored to the individual.

Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips


#5 Guest__*

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Posted 07 March 2010 - 09:37 PM

And when I first began on sinemet I would literally drop to the ground about 20 minutes after I ate. Actually this was stalevo that caused the problem after eating. I switched to regular sinemet and had to take it every two hours to get an effect and it took me probably three months before my dose was maximized and I found provigil stopped the narcolepsy or fainting or whatever which caused me to fall to the ground unconscious. So it can take quite a while before you find the optimum dose and food still causes me major problems with absorption - especially high fat meals and high protein and just eating too close to meds.

You have to stay on the doctor until you get the dose just right for you, but food can stop it from working totally for quite a while in some cases. I can go from normal to a quivery two year old in a matter of minutes if I eat the wrong thing too close to meds. It really works well though when you get it right. It's amazing how much better you'll be.

#6 Dr. Okun

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Posted 08 March 2010 - 03:42 PM

Thanks for the nice comments

Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips





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