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Post of the Week: Sildenafil to Treat Erectile Dysfunction in PD

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#1 Dr. Okun

Dr. Okun

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Posted 25 September 2010 - 01:32 PM

Dear Forum Members,

This trial was just published and shows promising results for patents with PD suffering from erectile dysfunction. Although this doesn't work in all patients (and there were some methodological issues with the trial) the data is promising and we need to develop better therapies. Here is the trial summary:

Int J Impot Res. 2010 Sep 23. [Epub ahead of print]
Safety and efficacy of sildenafil citrate in the treatment of Parkinson-emergent erectile dysfunction: a double-blind, placebo-controlled, randomized study.
Safarinejad MR, Taghva A, Shekarchi B, Safarinejad S.

Private Practice of Urology and Andrology, Tehran, Iran.
Parkinson's disease (PD) is one of the most commonly occurring neurodegenerative disorders, with lifetime incidence between 1 and 2% among people older than 65 years. ED is one of the more disabling and poorly addressed aspects of PD. The purpose of this study was to assess the efficacy and safety of sildenafil citrate in Parkinson-emergent ED. Sexual function of participants was assessed using responses to the 15-question International Index of Erectile Function (IIEF), Sexual Encounter Profile (SEP) diary questions 2 and 3, Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire and a Global Efficacy Question 'Has the treatment you have been taking over the study period improved your erections?' This randomized, double-blind, placebo-controlled study, comprised a screening period of at least 1 month, a placebo-lead in period of 1 week and treatment period. Two hundred thirty-six patients entered the trial. These patients had mild-to-moderate PD (stages I-III Hoehn-Yahr) and were experiencing Parkinson-emergent neurogenic ED. They were randomized to receive 100 mg sildenafil on demand 1 h before sexual activity (group 1, n=118), or similar regimen of placebo (group 2, n=118). Patients were instructed to use at least 24 doses/attempts at home. At the end of the trial, differences between sildenafil and placebo groups were significant for the IIEF erectile function (EF) score (22.6±4.6 vs 14.8±4.2, P=0.01), for percent Global Efficacy Question 'Yes' responses (68.1±4.6 vs 12.2±3.2, P=0.001), for SEP2 'Yes' responses (68.1±4.2 vs 32.5±2.2, P=0.003), for SEP3 'Yes' responses (75.9±5.4 vs 33.5±4.4, P=0.004) and for mean EDITS score (69.8±4.2 vs 13.0±2.7, P=0.004). A normal EF domain score (26) at end point was achieved by 56.9 and 8.7% of the patients in the sildenafil and placebo groups, respectively (P=0.001). Sildenafil can be considered as an effective treatment in patients with Parkinson-emergent ED.International Journal of Impotence Research advance online publication, 23 September 2010; doi:10.1038/ijir.2010.23.

PMID: 20861846 [PubMed - as supplied by publisher]

Michael S. Okun, M.D.

Author of Amazon Kindle, Paperback and Audio of 10 Breakthrough Therapies for Parkinson's Disease
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips

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