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What's Hot in Parkinson's Disease Blog: Eight Sinemet Rule


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#1 Dr. Okun

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Posted 17 November 2010 - 08:49 AM

Dear forum members,

Check out Dr. Okun's blog this month:

http://www.parkinson...n-The-Blog.aspx

Does the FDA really recommend not to exceed 8 sinemet a day?

Michael S. Okun, M.D.
Author of the Amazon Bestseller Parkinson's Treatment: 10 Secrets to a Happier Life
National Medical Director | NPF
UF Center for Movement Disorders & Neurorestoration
Read More about Dr. Okun at: http://movementdisor...hael-s-okun-md/
or Visit Parkinson's Disease treatment and research blogs at:
NPF's What's Hot in Parkinson's disease
or his parkinsonsecrets.com blog for treatment tips


#2 gmk

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Posted 18 November 2010 - 10:32 PM

Dear forum members,

Check out Dr. Okun's blog this month:

http://www.parkinson...n-The-Blog.aspx

Does the FDA really recommend not to exceed 8 sinemet a day?

Sinemet is a registered trade name by Merck pharmaceutical company located in State of New Jersey, USA, for the combination of L-DOPA and
Carbidopa, w/w 4:1 and 10:1, respectively. The company, actually, uses the FDA recommendation as the information for patients who have
been prescribed one or the other formulation of Sinemet. The interesting point is that at least 75 mg Carbidopa/daily is necessary to
complete blockage of aromatic aminoacids decarboxylase on periphery (outside of CNS)and to prevent nausea and vomiting caused by L-DOPA
alone. This combination has effectively permitted to considerable decrease the dose of L-DOPA needed for substitutional therapy of PDs.
gmk




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