I agree with the above statement from Beau's Mom.
In my 2.5 years experience with sinement I can tell you that I get about 12-15 hrs of on time with my current regime. I take 1.5 pills of 25/100 CL aka sinement and 1mg pill of Azilect at 7am then I take 1 pill of 25/100 CL every 3hrs till 7pm. When I go to bed at 10pm I take a 1/2 pill of regular CL and a pill of 50/200 extended release for over night. This has worked very well and I can say that for about 10hrs of the day I am 95% free of symptoms then in the evening when I am tiered I am about 75% free of symptoms till bed.
My thinking is why be sore and stiff when I don't have to be.
I hope this helps. Feel free to ask any question you would like.