Dear Dr. Okun,Aolo
My 82 year old husband was diagnosed with Parkinson's 20 years ago. He is still using a walker, exercises daily and walks at least a mile a day. Standing up from a chair seems to be a big problem, shuffling feet as well as getting tired and having to take a nap in the afternoon. We pointed out to the neurologist that the medications seem to wear out the four hour interval. Presently he is taking 8 mg Neupro patch, 1- 100 mg Amantadine, 1 - l mg Azilect and 8- 25/100 Sinemet for a total of 800 mg. He also has Botox injections every three months for drooling which has immensely helped. When we last saw our neurologist, she recommended that we could increase the Sinemet with one additional tablet - split 1/2 with the first AM dose and 1/2 tablet the third dose. We really have not seen much improvement. We also thought that there is a limit how much Sinemet you can take, but she said he can still take more. If she were to increase the Sinemet with an additional 100 mg, what kind of problems will he encounter? I have been reading where you have been recommending taking the Sinemet at a shorter interval rather than the four hour regiment. What are your thoughts on this matter?