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Discovery

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Discovery last won the day on November 27 2016

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About Discovery

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  • Birthday 10/25/1959

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    Okanagan Valley, Canada
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    Love to travel....love wildlife
  1. NEWS ARCHIVESRead News Parkinson's decline slowed with extended MAO-B inhibitors Monday March 06, 2017 Amy Wallace UPI - A study from the University of South Florida has shown that long-term use of MAO-B inhbitors may slow decline in patients with Parkinson's disease. Photo by sfam_photo/Shutterstock Researchers from the University of South Florida found in a retrospective analysis of clinical trial data that long-term use of monoamine oxidase type B, or MAO-B, inhibitors slows the clinical decline of patients with Parkinson's disease. Previous studies have shown MAO-B inhibitors produce neuroprotective effects in cell culture and animal studies of Parkinson's disease, but clinical trials had shown mixed results and appeared not to have a significant effect on Parkinson's disease symptoms. A secondary analysis of the NET-PD-LS1 clinical trial -- a multicenter, double blind, placebo-controlled study of 1,741 participants with early Parkinson's disease from March 2007 to July 2013 -- was conducted by researchers. Roughly 784 of NET-PD-LS1 participants received a MAO-B inhibitor and were assessed using the Global Outcome, allowing researchers to consider a combination of five measurements of change from each participant's baseline measurements. The new analysis revealed a significant link between longer duration MAO-B inhibitor use and slower clinical decline among Parkinson's patients, the researchers report. "Earlier large trials aiming to evaluate potential disease modifying effects of MAO-B inhibitors unfortunately suffered from confounding motor effects or yielded conflicting results," Dr. Robert Hauser, of the Department of Neurology, Molecular Pharmacology and Physiology at the University of South Florida, said in a press release. "Our study suggests that we should not give up on the potential long term benefits of MAO-B inhibitors. A definitive, rigorous, long-term trial should strongly be considered."
  2. MM...I'm wondering if you don't need 20% THC in the oil to notice a difference.. Also I read some sell you hemp oil which is not the same results... Keep posting your journey on the oil....I'm totally interested on how it goes!! Good luck buddy!! D
  3. Hey MM... i wish you great luck!!! When I arrive home I too will be trying CBD Oil....80% cbd 20% thc... Wilson the above poster has been a huge help to me in this area....thanks again Wilson.. D
  4. NN, I lost a friend to MSA. Sadly Joanie was diagnosed and in less then 5.5 years passed away. It was a blessing she did due to the last three years of her life. Wheelchair, spoon feed and only communicating with frustration and ilegiable printing. It's was a very sad and speedy death. I hope you find your answers and none being MSA. D
  5. Ella, i know it's been a long hard road for you....one that hasn't truly ended. You are more then welcome to hang around with us....glad you still want to....lol D
  6. Thanks Shaker Dave, very educational Do you know how her study went and if it's on you tube? It's a cliff hanger!!! Lol D
  7. Thank you Dianne, me too.....hope all is going well for you. D
  8. Hi there...I am pro MM and am looking to try oil by dabbing on tongue or cheek. I have no idea what I am looking for! I do not want THC in the oil. No buzz just tremor relief. I have right side Tremor and slight rigidity. Can someone guide me in what to look for? I live in BC Canada, known for our BC Bud , some say world renowned. It's legal here but I don't want BUZZ weed...YIKES Thank you D
  9. Ditto....sound advise... D
  10. I have always believed that Music heals .....even the deepest wounds.. Thanks for the post!! D
  11. SWVA, Good morning! I'm not use to reading these inserts. I'm on Azilect as mono therapy. I read that it is a condridiction to Sinemet CR. does this mean you can't take both? Thanks D
  12. Hey MM you're just a natural born swinger!! Good on ya!!! D
  13. Hi Sandal, I'm only on Azilect and have to date responded well to it..... Azilect has very mild benefits while using as Mono-therapy The Tremor Dominant is known to be the better Parkinson if there's such a thing.....slower progression..so I'm told!! Cheers D.
  14. Hello.. My symptoms started exactly like that. Bent at the elbow while walking and no arm swing. Eventually I started my Tremor. I can stand with arms to side and Tremor (postural tremor) or at resting position or action like walking. No pill rolling just shake. I am definitely Tremor Dominant. . D
  15. You're always helpful!!! Thanks D