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Marketfocus

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  1. Sinemet absorption with applesauce

    If more acidity helps with breakdown of Sinemet, what is the effect of taking proton pump inhibitors (PPIs)? Does this further diminish the absorption of Sinemet? What about other treatments for GERD (eg Pepcid, ranitidine , etc?). Thank you.
  2. Sinemet absorption with applesauce

    I would appreciate the recipe for putting Sinemet into a drink formula. I'm also wondering if chewing an immediate release Sinemet (maybe one of my two pills per dose) could help with absorption . Thank you.
  3. Barium swallowing study

    I've recently developed laryngitis and difficulty swallowing liquids (causing occasional coughing/aspiration) and my ENT has recommended a barium swallowing study . His exam found a vocal chord nodule - he thought due to acid reflux - and incomplete closure of my vocal chords due to this nodule. He has prescribed nexium to address the acid reflux . I noticed in previous posts you mentioned a dye is used in the swallowing studies. Is this the same as barium? I'm concerned about side effects of contrast agents, including constipation for barium as well as these agents aggravating my frequent migraines. Is barium advisable with PWP and/or are there other methods used to assess swallowing in Parkinson's patients? Thank you.
  4. I've recently developed difficulty swallowing liquids and am taking my medications including Sinemet with applesauce . I previously drank a lot of water and often took my Sinemet with sparkling water to enhance absorption . I'm wondering how this might now be affecting the absorption of Sinemet. I'm concerned about my fluid intake in general and will be seeing a speech pathologist soon to hopefully get some help. But it seems as if sinemet's effectiveness has decreased further since I started taking it with applesauce. I'm taking it still as whole pills, not crushed. How much does water affect the absorption of Sinemet? Would crushing the pills or any other strategies likely help? Thank you!
  5. I'm wondering about a gradual transition to Rytary from IR Sinemet, maybe one dose at a time versus a complete switch in one day. It seems that different doctors have different opinions on this matter. I have a difficult time adjusting to new medications and would feel more comfortable taking a very gradual transition approach rather than switching all at once according to the conversion chart (which seems to be best guess and would need some adjustment anyway). also, I was given some Rytary samples which expired in July. Are these still good or have they likely lost effectiveness? If I'm going to finally try this medication I'd like to at least make sure the trial is with samples that are still effective. Thank you very much!
  6. Rytary transition

    I'm interested in trying Rytary because I'm really not getting a good response from regular immediate release Sinemet. I'm wondering if there is a standard protocol for making the transition - my current MDS is recommending making the switch all at once (in one day) from Sinemet to the best guess daily dose of Rytary. Yet a previous Doctor thought it would be okay to change one dose at a time - I've also spoken with other PwP who successfully made a very gradual transition to Rytary. I have a very difficult time adjusting to new medications and would feel much more comfortable with a very slow and gradual transition process. Is this appropriate for a switch to Rytary, and if so, what might a general transition approach look like? Finally I have been given Rytary samples which expired a few months ago, in July. Are they still okay to use? (Seems like it would be better to use unexpired samples, particularly starting out, but maybe there is more latitude in the date when they lose effectiveness . . .?) Than you very much!
  7. Meclizine

    I'm wondering if Meclizine can be taken safely by PwP? A former neurologist suggested it might be helpful with the dizziness/vertigo I experience with migraines. Does it interact with Sinemet or is it otherwise contraindicated for persons with Parkinson's ? I have also read meclizine could potentially be neuroprotective. Is there any evidence to support that ? Thank you
  8. I've recently read that doxycycline might have some benefit in interfering with alpha synuclean clumping. Having been recently diagnosed with SIBO and the GI Doctor is recommending treatment with antibiotics (xifaxan), I'm wondering if doxycycline might also treat SIBO and be an alternative antibiotic treatment with other potential (although I realize unproven) PD benefits. Thank you.
  9. I've recently been diagnosed with small intestinal bacterial overgrowth (SIBO) and am wondering if this impairs Sinemet absorption? Also how is this best treated? With antibiotics, probiotics or diet? I've recently read that doxycycline may have some benefit to PD in terms of interfering with alpha synuclean clumping. Will doxycycline treat SIBO? I thought if it could treat SIBO and potentially have these other benefits,. It might be a good choice. Thank you.
  10. Does small intestinal bacteria overgrowth (SIBO) interferes with Sinemet absorption? Also how is this condition treated ? Are the effects similar to H pylori which I understand can impair the effectiveness of Sinemet? As always, thank you very much for your help!
  11. More informabout Xadago (safinamide)

    Thank you so much for your informative and thorough reply about how Xadago works! I appreciate your taking so much time to provide so much detail- this will be of great assistance as I evaluate how to proceed. Thanks
  12. More informabout Xadago (safinamide)

    How does the mechanism of action of Xadago compare to how Azilect works? Does Azilect modulate glutamate release as well or does it work some other way? One reason I'm wondering is that I was unable to take Azilect as it aggravated my migraines. However, I do take topamax for migraines which I thought affected/calmed down glutamate in some way. So I'm hoping I may be able to tolerate this new drug if the mechanism of action modulates glutamate and therefore might not aggravate my migraines. (The chemistry is really over my head but I sure would like another option!). Thank you!
  13. Xadago

    How does the recently approved new drug Xadago compare with other MAO-B inhibitors such as Azilect? Thank you.
  14. Sinemet IR and CR

    I'm working with my doctor to switch from taking all Sinemet IR during the day to a combination of IR and CR in order to hopefully get more on time. If I'm switching a dose that was formerly e.g. 1.5 or 2 tablets of 25/100 IR to a combination of IR and CR, would it be better to take one tablet of the IR and then wait an hour before taking the CR tablet, or is it fine/better to just take them together? Also I was generally waiting 3.5 to 4 hours between doses while on all IR Sinemet. How should the timing between doses be adjusted with this combination of IR and CR? Thank you very much!
  15. CR vs IR and eating

    I seem to remember you mentioning taking Rytary in the past. In your experience, how does the Rytary compare to the regimen you just mentioned with the combination of Sinemet IR and ER in terms of effectiveness and side effects? It seems I've heard more favorable comments about using ER and many comments about difficulty getting the Rytary dose right. I'd appreciate your perspective on this. Many thanks!
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