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  1. I was diagnosed with PD over a year ago. I had been taking Azelect plus 4 tablets of Sinemet daily. This regimen provided some relief but it did not relieve my tremors which were significant and worsening especially in my predominate right hand. In September, I came across an article entitled Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson’s disease which was published on September 2, 2013 in Brain. (See: http://brain.oxfordjournals.org/content/early/2013/09/02/brain.awt224.full.pdf) When I saw my Neurologist on September 25, he told me that he was not familiar with this article. He did recommend that I increase my Sinemet dosage to 6 tablets per day to reduce my tremors. Later that same day, his office called me. He read the article and was willing to issue me a prescription for 300mg of Ursodiol to be taken twice per day. From September 25th through October 16th, I was taking the increased dosage of Sinemet. But, it did not seem to reduce my tremors. On October 16th, I started taking Ursodiol. On October 17th, my tremors were almost gone. As of this date, I am still almost tremor free due to the effects of Ursodiol. I saw my Neurologist today and he was pleasantly surprised with the results. I thought I would like to share this information with the group. Although Ursodiol may not work for everyone, I thought some of you may wish to give it a try or at least discuss this with your doctor. Please note however that Ursodiol does have side effects. Fortunately for me, I have not experienced any. Please feel free to contact me if you have any questions regarding this post.