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  1. Good day for everybody! Happy to find this forum! My name is Tamara and I am from Moscow, Russia. I,m 50 years old and live with PD diagnosis since january 2012, first sings at jan 2010. I have aquinetic and rigid form , no tremors. I take now pramipexol 0,7 mg + amantadine 1 mg + akineton (holinolitic group) 0,5 mg + macuna pruriens 1 capsule 3 times a day. I,m steel working, drive a car manage my house and take care of my family - 2 sweet sons and hasbend. Rarely exercise now and 4 mounth ago i stoped azilect , since stop azilect feel myself much more better. So that is my small story. Thank you for reading. I have some questions and highly appreciate all answers 1. Is sinemet nowdays best levadopa-carbidopa drug? 2. Is it better to start take levadopa treatment with sinemet or leave it for a future ? 3. Most part of you as i understood from posts are using Sinemet from 6-12 mounth from diagnosis date. Here most of neurologists and PDP prefer to postpone levadopa treatment as long as possible, what is your opinion? I have seen some of you use isradipine in trials - how do you do and do you feel any improvements? Thank you for your support and attention All the best and really sorry for my school English. Have a nice day