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  1. Hi everyone, My mother has Parkinson's disease, and has been taking levodopa medication for around 15 years now. Recently, she discovered she has a gastro inflammation that must be taken care of. However, the pills fighting the inflamation distrub her L-dopa medication, resulting in many more off periods than usual. She had tried numerous pills (including Omeprazole, Famotidine, Nexium (Esomeprazole) and Dexilant (Dexlansoprazole)), and while some were better than others, all hurt the affect of her L-dopa medication. We have discussed this with doctors and searched the web independently, but found no mention of this problem. I assume many people had this combination of drugs, though, because acidic reflux (a possible cause of the inflammation) is common in Parkinson's. Had someone here perhaps had this experience, or taken these pills with no such problem? Does someone perhaps know of an MD that specializes in gastro-related issues in Parkinson's, or can refer us to another good source of information? Thanks very much in advance, and good health to everyone, Amir