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Dr. Okun, I understand your position along with most of the other major Parkinson organizations, the Mayo Clinic, the Cleveland clinic etc. has been there is no reason to delay the start of carbidopa levodopa therapy. Does this most recent study from Alabama change anything? https://parkinsonsnewstoday.com/2016/08/04/researchers-discover-why-l-dopa-stop-working-parkinsons-seeking-prolonged-treatment/#at_pco=tst-1.0&at_si=5a8b566bbfca2f61&at_ab=per-2&at_pos=0&at_tot=2