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Hi Mark, I am currently taking carb/levo ER 25-100, 4 times per day at 7a, 11:30a, 3:30p, 7:30p. It helps, however the last hour before I take the next dose, I have a wearing off period. I've heard that rytary would help with the off time or you've mentioned a combination of regular C/L combined with C/L ER. Which do you think would be a good place to start and could you explain the regular and ER combination method as I didn't quite understand the timing of that. Thanks for all your tireless help. Any help suggestions from others who have the same situation would be appreciated.