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  1. I’ve been taking Sinemet 25/100 for about four years. Some time after I started taking it, “on” and “off” times became very distinct. My last dose of the day is at 5:30 in the afternoon and this takes me up to bedtime at 10:00, when the medication starts wearing off. I get up at six in the morning, so that’s almost 12 hours since the last dose the day before. The odd thing is that when I wake up I’m very much “on”, and this lasts for one to two hours. I feel almost normal, like in my pre-PD days. From what I’ve read on the forum, this is completely the opposite of what other people experience – they are off when they wake up and need their meds to to make a start to the day. Does anyone have an explanation for my “reverse” condition, and are there others who have the same experience? Somehow I seem to manufacture dopamine while I’m asleep.