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woodbee

N-acetyl cysteine

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Dr. O.,

 

What can you share with PWP regarding the use of n-acetylcystein? Are you aware of any studies supporting it's use for PWP or in helping ameliorate compulsive behaviors. Would it be safe to use it with typical PD medications such as sinemet, and dopamine agonists. If you are aware of benefits or side effects would you share that info also please.

 

thank you , in advance

Eileen

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Dr. Okun,

 

I went off Azilect to start Wellbutrin. Prior to going off Azilect my Parkinsons symptoms were almost completely under control. I am now trying to get off Wellbutrin. My neurologist currently has me taking 25-100 CL four times a day (1&1/2, 1, 1&1/2, 1). Since being off Azilect and being on the current CL regimen my Parkinsons symptoms have been much worse. I have constant tremors (hands & legs), including internal tremors. I am considering going back on Azilect? Do you agree? Do I have to wait two weeks after stopping Wellbutrin to start Azilect? I thought that I read or heard that requirement had changed.

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My sister recently participated in an Exercise Retreat for PWP near Phoenix, Arizona. One of the guest speakers was a Movement Disorder Specialist that recommended N-Acetyl Cysteine (NAC)for PWP. Isn't glutathione a fairly strong antioxidant that is decreased in PWP? Do you think a dose of 600 mg NAC, twice a day (total 1,200 mg/day)would be safe for a PWP even though the studies specific to Parkinsons haven't been completed yet?

 

As always, your thoughtful answers are appreciated. NPF provides a wonderful service through these forums. I could also post on the Nutrition Forum for Kathryne's thoughts as well.

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One solution is to increase sinemet dose.

 

In our clinic we allow SSRI antidepressants and Wellbutrin with MAO-B drugs like azilect (we monitor, but haven't had problems....MAO-A's are the problem).

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There is no data to support or refute clinical use of NAC in PD, and no safety data although I suspect it is probably safe.

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