Jump to content
  • Announcements

    • ForumAdmin

      Frequently Asked Questions - Step by step guides

      Do you need assistance registering, logging in, posting, etc? Please visit the all new Frequently Asked Question Forum for step-by-step guides. Click the link below to access these helpful guides. Frequently Asked Questions
    • ForumAdmin

      Recursos Nuevos en Español

      http://www.parkinson.org/ayuda   http://www.parkinson.org/espanol    
    • ForumAdmin

      Línea de Ayuda 1-800-473-4636

      Línea de Ayuda 1-800-473-4636   ¿Qué es la línea de ayuda 1-800-4PD-INFO (473-4636) de la Fundación Nacional de Parkinson? Es un número de teléfono gratuito que ayuda a las personas con la enfermedad de Parkinson, sus familiares, amigos y profesionales de salud, a solucionar diferentes inquietudes.   La línea de ayuda ofrece: Información actualizada Apoyo emocional Referidos a profesionales de salud Recursos comunitarios Amplia variedad de publicaciones gratis    
Sign in to follow this  
Dr. Okun

Post of the Week: PLA2G6 New Area of Genetic Interest in Parkinson's Disease

Recommended Posts

Dear forum members,


Researchers have identified the PLA2G6 gene as an area of potential interest to Parkinson's disease. The findings are summarized in the journal Movement Disorders. The abstract is below:



Mov Disord. 2011 Aug 2. doi: 10.1002/mds.23851. [Epub ahead of print]

The PLA2G6 gene in early-onset Parkinson's disease.

Kauther KM, Höft C, Rissling I, Oertel WH, Möller JC.


Department of Neurology, Philipps University, Marburg, Germany.



The definite etiology of neurodegenerative disorders such as Parkinson's disease (PD) is still unknown. Because of its role in the generation of reactive oxygen species and its association with neurodegeneration with brain iron accumulation, a possible involvement of calcium-independent group VI phospholipase A(2) (iPLA(2) -VI) in the pathogenesis of PD has been proposed.



In this study we analyzed all 17 exons of the PLA2G6 gene encoding iPLA(2) -VI in a group of 102 discordant pairs with early-onset Parkinson's disease (EOPD) and an additional sample of 166 EOPD patients and 155 unrelated controls.



The nonsynonymous single-nucleotide polymorphisms (SNPs) 2339A>G (n = 2) and 2341G>A (n = 1) in 2 neighboring codons were found in 3 patients with typical L-dopa-responsive sporadic EOPD and in none of our controls, indicating a possible role of PLA2G6 in the pathogenesis of EOPD in rare cases.



Future studies should investigate the prevalence of these SNPs in other PD populations and larger control groups and also address possible genetic alterations in the remaining parts of the PLA2G6 gene. © 2011 Movement Disorder Society.


Copyright © 2011 Movement Disorder Society.

Share this post

Link to post
Share on other sites
Sign in to follow this