Jump to content
  • Announcements

    • ForumAdmin

      Frequently Asked Questions - Step by step guides

      Do you need assistance registering, logging in, posting, etc? Please visit the all new Frequently Asked Question Forum for step-by-step guides. Click the link below to access these helpful guides. Frequently Asked Questions
    • ForumAdmin

      Recursos Nuevos en Español

      http://www.parkinson.org/ayuda   http://www.parkinson.org/espanol    
    • ForumAdmin

      Línea de Ayuda 1-800-473-4636

      Línea de Ayuda 1-800-473-4636   ¿Qué es la línea de ayuda 1-800-4PD-INFO (473-4636) de la Fundación Nacional de Parkinson? Es un número de teléfono gratuito que ayuda a las personas con la enfermedad de Parkinson, sus familiares, amigos y profesionales de salud, a solucionar diferentes inquietudes.   La línea de ayuda ofrece: Información actualizada Apoyo emocional Referidos a profesionales de salud Recursos comunitarios Amplia variedad de publicaciones gratis    
Sign in to follow this  
MComes RPH

Study reports: Two antidepressants decrease depression in Parkinson's patients

Recommended Posts

Two antidepressants decrease depression in Parkinson's patients, study finds

Apr 12, 2012

By: From staff reports

Drug Topics Hospital Pharmacists' Report



Certain antidepressants decrease depression in people with Parkinson’s disease without worsening their motor problems, according to a new study.


Published in the April 11, 2012 online issue of Neurology, the medical journal of the American Academy of Neurology, the study was led by Irene H. Richard, MD, with the University of Rochester Medical Center, New York.


Richards and colleagues conducted a clinical trial involving the antidepressants paroxetine and venlafaxine extended release with 115 people in various stages of Parkinson’s disease, who met the criteria for depression.


On average, the patients who received paroxetine demonstrated a 59% improvement in their depression scores, based on the Hamilton Rating Scale for Depression. Those who were taking venlafaxine had a 52% improvement in their scores. “These results are exciting, because depression is common in Parkinson’s, but we weren’t sure about the best way to treat it,” Richard said.


Older antidepressant medications are effective, but have numerous side effects, according to Richard. “The newer antidepressants have fewer side effects, but we didn’t know if they’d be effective in people with Parkinson’s. We were also worried that they might worsen the motor problems that come with the disease,” Richard said. The drugs were generally well tolerated and did not cause worsening in motor function, according to the study.

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Sign in to follow this