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Sinimet ER ineffective

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I take one half of a regular Sinimet (25/100) and 1 Sinimet ER (25/200) six times a day. I also take Requip ER 8mg at bedtime. Sometimes the Sinimet ER just doesn't seem to work. Some days my cycle works fine, on other days I become extremely rigid (difficult to walk even with a walker) at times when my sinimet should be at a high level.


As a test, for two days i ate as little protien as possible. That helped, but did not eliminate the problem.


If i do nothing, I my legs often stay rigid until the next sinimet pill. If I take another half of the regular Sinimet I generally loosen up in half an hour.


I am 60 and was diagnosed with Parkinson's in 2006.


This problem started about two months ago. It is making me reluctant to go to parties or events, becuase i do not know when it will occur.


Can you recommend additional things that I could try?

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I would see your doc. I would be sure to take your meds at exact times and equally spaced (for example every 3 or 4 hours exactly). I would give your meds a one hour head start before eating. Finally you may want to switch to regular sinemet which has 20% or so more pop. You may simply be undermedicated and need your doc to increase dose. Don't forget physical and occupational therapy.

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