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Wondermom

LRRK2 familial PD

7 posts in this topic

I was diagnosed at 42 (I'm about to turn 50). My sister at 46, my mother at 65. We are LRRK2 carriers. Ashkenazi Jews. Anyone else have family PD? YOPD?

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I was diagnosed about a year ago, but had the symptoms for years (ignorantly not knowing what they were). I just had the genetic bloodwork done a few months ago, and came up positive for a mutation on my LRRK2 gene. Weird thing is, they said ironically that it didn't cause my PD. The genetic counselor told me last week that the specific mutation I have didn't penetrate the gene enough! I don't know anymore...I have a fam history of neuro disorders, but no PD. The whole thing have left me guessing even more as to where I got it from.......frustrating! I will say Sinemet has worked WONDERS for me though!

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Wondermom,

 

I'm new to this forum. I was diagnosed when I was 42. I found out from 23 and Me I have LRRK2 gene. In fact, they asked if my first degree relatives would give genetic samples. They all agreed. I am an Ashkenazi Jew and have participated in the clinical trials for Ashkenazi Jews (they are looking for biomarkers) as well as a trial for early onset (Michael J. Fox Foundation Trial Finder has more info on the trials.

 

My paternal grandfather had PD as well as one of his brothers. What is it you would like to know?

 

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Hello SolarPD,

Welcome to the YOPD Forum... I hope you are settling in and find our abode to your liking!

We're all here to jump on any questions you may have, so feel free to fire away!

Kim

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I was diagnosed at 41 with PD and my Dad had it as well, though he developed his later in life. After some research, we discovered several other people on my father's side that had PD or PD like symptoms. My doctor urged me to get the genetic testing done and I have submitted my DNA, just waiting on the results. He said if I carry the gene, its possible my brother and my son could have it as well.

Edited by dgray001

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I don't know if my PD is genetic, there are 3 of us in my family, me, Mom and Dad. Me and Dad are both YOPD, although Dad was diagnosed almost 30 years ago and still kicking. Our whole family, including all 7 of my siblings are participating in the PaGeR (The Parkinson's Genetic Research Study) being conducted by the University of Washington and the VA Puget Sound Health Care System. This is the web site, http://depts.washington.edu/pgrgroup/

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