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ShakingTheChi

Tremors/Wearing Off After Exercise

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Dr. Okun,

 

I am taking Sinemet (25/100) and Comtan 3x a day at a 3.5 hour interval, which on a good day reduces my tremor to a fairly consistent, mild level I am comfortable with. I exercise frequently, and I notice that after an intense workout my tremor increases markedly. Others in my support group note the same phenomenon. Does exercise burn the levodopa at a faster rate than it's normally metabolized? If so, can we adjust the medication to anticipate a heavy workout, either adding an extra Sinement or fraction of it or accelerating the next dose (or fraction of it)? 

 

Thanks!

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We don't know exactly why this phenomenon of heavy exercise can make some PD symptoms worse (especially post-exercise).  It could be stress on the system, metabolism or other factors.  In cases where it requires treatment we sometimes add 1/2 to one sinemet tablet just before exercising.

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