Jump to content
helplinedonate
  • Announcements

    • ForumAdmin

      Frequently Asked Questions - Step by step guides

      Do you need assistance registering, logging in, posting, etc? Please visit the all new Frequently Asked Question Forum for step-by-step guides. Click the link below to access these helpful guides. Frequently Asked Questions
    • ForumAdmin

      Recursos Nuevos en Español

      http://www.parkinson.org/ayuda   http://www.parkinson.org/espanol    
    • ForumAdmin

      Línea de Ayuda 1-800-473-4636

      Línea de Ayuda 1-800-473-4636   ¿Qué es la línea de ayuda 1-800-4PD-INFO (473-4636) de la Fundación Nacional de Parkinson? Es un número de teléfono gratuito que ayuda a las personas con la enfermedad de Parkinson, sus familiares, amigos y profesionales de salud, a solucionar diferentes inquietudes.   La línea de ayuda ofrece: Información actualizada Apoyo emocional Referidos a profesionales de salud Recursos comunitarios Amplia variedad de publicaciones gratis    
kholden

Does vitamin D provide a treatment effect for Alzheimer’s patients?

Recommended Posts

kholden    707

Both older adults, and people with PD generally, have been found low-to-deficient in vitamin D. I encourage everyone to be sure to have a baseline test for 25(OH)D, the test for serum levels of vitamin D in the human body, so that your doctor can know whether or not you need supplements (or in deficiency, injections) of vitamin D. -Kathrynne

 

 

 

 

Does vitamin D provide a treatment effect for Alzheimer’s patients?

shutterstock_11483386-1-620x414.jpg

 
7

A few months ago we published a truly remarkable study in JAMA neurology that showed older subjects were almost three times more likely to develop dementia if they had low 25(OH) levels.

Closer look: low vitamin d status may increase risk of dementia

Now, a group from Arizona headed by Dr. Brendan J. Miller may have found one of the ways vitamin D helps dementia.

Miller Bj, Whisner Cm, Johnston Cs. Vitamin D Supplementation Appears To Increase Plasma Aβ40 In Vitamin D Insufficient Older Adults: A Pilot Randomized Controlled Trial. J Alzheimers Dis. 2016 Mar 31.

In Alzheimer’s disease, plaques of amyloid-B (AB) build up in the brain. This is thought to be due to decades of free radicals and oxidation. If some method was found to remove those plaques, it might help patients with Alzheimer’s. If something was useful in breaking down plaques of AB, then the amount of AB in the blood would increase as AB would be transported away from the brain to be catabolized by the liver.

A total of 19 subjects were randomized into two groups. The treatment group received 50,000 IU of vitamin D3 per week for eight weeks, while the control group received a placebo pill. Both groups had baseline 25(OH)D of around 24 ng/ml. The treatment group’s vitamin D level increased to 51 ng/ml while the placebo group remained unchanged.

Plasma AB increased by 15 ng/ml in the treatment and 13 ng/ml in the placebo group. Significance was p= 0.045; however, when exercise was accounted for, this finding just became a trend. Though, when only examining subjects >60 years of age, AB increased by 18 ng/ml in the treatment group and fell by 3 ng/ml in the placebo group. In older subjects the change in 25(OH)D and the change in plasma AB was significantly correlated (r2 = 0.176).

The authors concluded:

“In conclusion, we show the potential for vitamin D as a primary treatment strategy …”

Should patients with Alzheimer’s be given vitamin D? There are many mechanisms by which vitamin D might prolong their lives. However, whether vitamin D improves the individual’s disease state is yet to be determined. Therefore, further randomized controlled trials evaluating the role of vitamin D in the treatment of AD are needed.

 

http://www.vitamindcouncil.org/blog/does-vitamin-d-provide-a-treatment-effect-for-alzheimers-patients/?mc_cid=2d91a25978&mc_eid=3289f2d512

 

Share this post


Link to post
Share on other sites

×