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Rytary and Dyskinesia

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Hello Dr,


My mother of PD, 35+ years, age 79, has had success with Rytray since it hit the market.  I am now witnessing alot more biphasic dyskinesia.  She already takes Amantadine (100mg)....  She has alot of tongue/jaw movement which makes drinking/speaking very difficult.  The only other thing that worked for her before Rytary was liquid sinemet, however she is now in LTC, so scheduled meds is my only option.  We are seeing her neurologist next week, however I was wondering what you might suggest.  I feel as if the levadopa in the Rytary is simply too much.  She currently only lasts about 2.5 hours in between doses, and currently takes 23.75/95mg at the following times: 3pills@8am,  4pills@1030am,  4pills@1pm  , 3pills@330pm


The dyskinesia is in her leg, shoulder, and tongue/mouth... 


Do you have any suggestions?  Thank you.


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We sometimes can decrease the number of Rytary pills at each dose by 1 and possibly 2 and limit dyskinesia.  Also instead of Rytary you and your doc could try low dose sinemet every 2 hours.

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