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Skiing

l dopa making symptoms worse

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I have been diagnosed 4 years ago. Ldopa has no positive effect on my pd symptoms. So i had a l dopa challenge again. Not only did my symptoms not improve but they actually got worse particularly my rigor and pain. Mds told me he has never seen such a reaction and is at a loss. My solution so far has been to go without medication. Unsure what to do now? Thanks.

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I usually get a GI emptying study and recommend a second opinion to see if this is actually PD or a look a like.  It could also be that the medications are not absorbing and the GI emptying study and sometimes apomorphine injections can be helpful.

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Thanks. Would absorption problems also intere with the soluble ldooa challenge test? It seems to me that it does get absorbed since stiffness and pain increase considerable with ldopa

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No one seems to be questioning the pd diagnosis. All they said was that i would long be in a wheelchair if it were atypical pd

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Absorption can in some cases interfere with a dopamine challenge test; in these cases I use injectable apomorphine to look for a response.  Not everyone reaches a wheelchair and I try not to generalize too much though atypical parkinsonisms are usually more severe and harder to treat,

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