Jump to content
  • Announcements

    • ForumAdmin

      Frequently Asked Questions - Step by step guides

      Do you need assistance registering, logging in, posting, etc? Please visit the all new Frequently Asked Question Forum for step-by-step guides. Click the link below to access these helpful guides. Frequently Asked Questions
    • ForumAdmin

      Recursos Nuevos en Español

      http://www.parkinson.org/ayuda   http://www.parkinson.org/espanol    
    • ForumAdmin

      Línea de Ayuda 1-800-473-4636

      Línea de Ayuda 1-800-473-4636   ¿Qué es la línea de ayuda 1-800-4PD-INFO (473-4636) de la Fundación Nacional de Parkinson? Es un número de teléfono gratuito que ayuda a las personas con la enfermedad de Parkinson, sus familiares, amigos y profesionales de salud, a solucionar diferentes inquietudes.   La línea de ayuda ofrece: Información actualizada Apoyo emocional Referidos a profesionales de salud Recursos comunitarios Amplia variedad de publicaciones gratis    
Sign in to follow this  

Sinemet & Dementia with Lewy Bodies

Recommended Posts

I have a solid diagnosis of DLB mixed with Alzheimer's. I'm 66 and 185 pounds, male. I got my diagnosis at a major medical center's memory assessment clinic, but I am seeing a local neurologist for management of medications that were recommended by the center. I'm on Exelon, Celexa, and a bunch of other stuff and some heart medications for stable heart failure. I started Sinemet one-half 25/100 3 times per day a week ago with no problems. My neurologist told my wife (a doctor) to move me on up to one full pill of 25/100 3 time per day. If all goes well, what is the normal next step up. I'm taking these for the Parkinsonian movement, muscle, stiffness, pain stuff. Just trying to get an idea, as my wife won't tell me anything other than see the neuro and go the PT. I'm set to see the neuro in two months, but he will discuss med adjustments with my wife along the way based on what I told my wife. This is a little different I know, but that is kind of how it works where we live. Thanks for any information. I realize you only can make generalized comments and nothing specific for my case.

Share this post

Link to post
Share on other sites



Thanks for the information and the question. What you should expect with Sinemet, as well as most medications for Parkinson's Disease, is that one will start off at a standard dose and that dose will be increased if need at small increments over a period of time. This dosing regime is what I like to call the "Start low and go slow" regime. Small increases in dose of Parkinson's medication can make a big difference because we are dealing with brain chemistry. Increasing a medication too high or too fast can have severe consequences.


In your situation you started at 1/2 tablet and then increased to one tablet. The next step would probably be 1 & 1/2 tablets 3 times per day unless you are having issues at a certain time of the day. For example, if you start having difficulty managing symptoms in the morning there would be no reason to increase all of your doses throughout the day. Instead, it would be reasonable to target the dose at that time of the day and increase that a small amount. No matter if it one of the doses in the day or all of the doses in the day that need to be increased, all of those individual doses should adhere to the "Start low and go slow" philosophy.


I hope this helps and please keep me posted. Good luck. 

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Sign in to follow this