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Dancing Bear

Requip XR/XL

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I take a 6mg XL dose of Requip at 6am with my first of 4 daily doses of Sinemet 25/100. What is the advertised life of this Requip dose? I am guessing it covers the day basically and that is it.


Thanks for your time!

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The duration of a medication is determined by what is called it's Half-life. Half is the amount of time it takes for one-half of the medication to be eliminated from the body. Requip XL has a half-life of about 6 hours. This means that when the medication is taken orally it will be slowly released into the body and the maximum concentration will be about the 6 hour mark. This maximum concentration can last anywhere from 30 to 60 minutes, which at that time the concentration will slowly decrease and will reach around zero at approximately 12 hours or so.

Many of the manufacturers state that their sustained release, extended release, SR, ER, CR, or XL tablets are a once a day dosing. This means "hours of being awake." Which to most people can range from 12 hours up to 16 hours. Sometimes this is a miconseption amongst the population which believe a once-a-day medication probably lasts 24 hours.

I hope this helps an please keep me posted

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