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Carbidopa/Levodopa ER Onset

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Hi Mark! Can you tell me what is the onset and peak of the carbidopa/levodopa extended release? Some websites show unknown other 4-6. Thank you.

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The onset of action of Sinemet CR is 30 minutes to 45 minutes. The medication is available in low amount after being metabolized and having much of the medication being released over the 4 to 6 hour period then decreasing in plasma concentration as the medication is expelled from the system.

When you look at the mechanism of the medication it will show that the peak plasma concentration happens after about 2 hours. What we have to remember is that it will pass in the blood before it will cross the Blood Brain Barrier, where it works. So that is why it appears there is a discrepancy between Peak plasma concentration of 2 hours and the medication reaching it's release time of 4 to 6 hours.

I hope this helps and please keep me posted. 

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