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GURUTEGH

levels of sinemet in brain

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GURUTEGH    0

we have an idea about peak serum levels and 1/2 life of sinemet plus etc. can you say anything about the levels of sinemet in the brain?

Why is the dosing of sinemet 3 - 4 times a day and not more often?

 

thank you for your time.

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Dr. Okun    411

Sinemet has a short half life in the neighborhood of 1-2 hours but in early PD it lasts longer and in more progressive and longer duration PD it may last shorter intervals.  That is why it is necessary to change dosing intervals as the disease progresses.

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GURUTEGH    0

Thank you for your response. Have dopamine levels been measured in the brain post sinemet?

 

This may not be of practical importance because regardless of what the levels are, I am focusing on symptoms.

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Dr. Okun    411

This is not typically done in the clinic or in clinical research.

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