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Small intestinal bacterial overgrowth and Sinemet absorption

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Does small intestinal bacteria overgrowth (SIBO) interferes with Sinemet absorption? Also how is this condition treated ?  Are the effects similar to H pylori which I understand can impair the effectiveness of Sinemet?  

As always, thank you very much for your help!

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We know suprisingly little on this topic of small bacterial overgrowth and Parkinson.  We reviewed a paper on the PF What's Hot in Parkinson Blog recently and you may want to check that out.  At this time it is unclear whether and in who to treat; also using antibiotics has the potential of harm.  At this time most PD experts refer to GI experts as we wait for more studies.  We believe it likely impacts outcomes and absorption.

Here is the piece we recently wrote:

http://www.parkinson.org/find-help/blogs/whats-hot/january-2015

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Thanks for the article, Dr. Okun. Very interesting. I have had perforated duodenal ulcers this year and was diagnosed with SIBO last fall. Since I use Duopa, I wonder if the absorption issue would affect me as much as it does with someone who takes carb/levo orally? Perhaps that is a question for my gastroenterologist.

Dianne

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I've recently read that doxycycline might have some benefit in interfering with alpha synuclean clumping.  Having been recently diagnosed with SIBO and the GI Doctor is recommending treatment with antibiotics (xifaxan), I'm wondering if doxycycline might also treat SIBO and be an alternative antibiotic treatment with other potential (although I realize unproven) PD benefits.  Thank you.

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I am not aware of any good data to support this use in humans.  You have to be very careful with antibiotics for general health concerns so we usually focus the decision on the GI docs assessment of needs.

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