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MarcB

longvida curcumin & nilotinib

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IMHO seems likely Curcumin, especially Longvida, is helpful for pwp.  I'd like to start, but I'm taking Nilotini and a primary concerns with Niotinib is that it is known to prolong the QT interval.b.  This link says Curcumin prolongs the QT interval.  I've read a lot about Curcumin, but never anything re QT prolongation.  Have you? (They have a fix for that problem.  "Here we show a curcumin encapsulated lipopolymeric hybrid nanoparticle formulation which could protect against QT prolongation and also render increased bioavailability and stability thereby overcoming the limitations associated with curcumin.)      So, my question is, can I take Longvida Curcumin and Nilotinib?

https://link.springer.com/article/10.1186/1477-3155-11-40

 

 

Edited by MarcB
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I would not recommend taking the two medications together due to the prolonged QT wave issue. If the two are combined it cause a 1+1=3 effect. That is where you take two medications that cause the same issue and, when added together, could cause a more severe issue.

I have actually been doing research on PD and prolonged QT wave syndrome. I had it happen to me and the cause was "unknown." After speaking with several patients, Dr's, and Movement Disorder Specialist about this issue their interest peaked. So far it is a small sample size, but the physicians who had patients who had falling episodes or passing out issues sent their patients in for testing. At this moment only 10 PD patients have been tested and 7 out of 12 have shown prolonged QT wave syndrome.

With this information, I believe it would be in your best interest not to take the two together.

I hope this helps and please keep me posted.

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Dear Pharmacist and MarkB,

                               Your discussion on Nilotinib arouse my interest.As this medication being approved for treating PD by FDA?I no there was a trial study on small group of pwp,which yielded a positive result.But currently there is a recruitment ongoing for a larger study.Does curcumin have the same beneficial effect like Nolitinib?

MarcB, are you participating in the Nolitinib study? How long have you been taking this medication?Has is helped to slow down your PD?

Dear Pharmacist, will any MD prescribe Nolitinib for me,despite not being approved by FDA for treating PD.

Thanks for your anticipated response.

 

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Otolorin,

Curcumin is a potent natural anti-oxident which works on inflammation and has been said to help with PD symptoms. Nilotnib, brand name Tasigna is a leukemia medication that is in a Phase 2 study for the use in  PD.

I am not aware of when, or if, it will be moving to a Phase 3 study but does look promising. So, knowing this, I am not sure if a DR would be will to prescribe it to you due to the side effects it has.

I will keep you posted if I find out any further information.

I hope this helps and please keep me posted.

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7 hours ago, otolorin said:

Dear Pharmacist and MarkB,

                               Your discussion on Nilotinib arouse my interest.As this medication being approved for treating PD by FDA?I no there was a trial study on small group of pwp,which yielded a positive result.But currently there is a recruitment ongoing for a larger study.Does curcumin have the same beneficial effect like Nolitinib?

MarcB, are you participating in the Nolitinib study? How long have you been taking this medication?Has is helped to slow down your PD?

Dear Pharmacist, will any MD prescribe Nolitinib for me,despite not being approved by FDA for treating PD.

Thanks for your anticipated response.

 

As this medication being approved for treating PD by FDA?  Probably not for 6 - 8 years.

Does curcumin have the same beneficial effect like Nolitinib? No.

https://examine.com/supplements/curcumin/

MarcB, are you participating in the Nolitinib study?  No.

How long have you been taking this medication? 2 mos, 120 mg/day. 

Has is helped to slow down your PD?  No effect - yet.

Dear Pharmacist, will any MD prescribe Nolitinib for me,despite not being approved by FDA for treating PD.  No

Marc

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On 8/2/2017 at 2:37 PM, otolorin said:

Dear Pharmacist and MarkB,

                               Your discussion on Nilotinib arouse my interest.As this medication being approved for treating PD by FDA?I no there was a trial study on small group of pwp,which yielded a positive result.But currently there is a recruitment ongoing for a larger study.Does curcumin have the same beneficial effect like Nolitinib?

MarcB, are you participating in the Nolitinib study? How long have you been taking this medication?Has is helped to slow down your PD?

Dear Pharmacist, will any MD prescribe Nolitinib for me,despite not being approved by FDA for treating PD.

Thanks for your anticipated response.

 

otolorin,

greetings.

Regrettably, after I read the pharmacist reply I didn't come back to this site.  I participate in the Parkinson's forum on the healthunlocked website.

I believe there's a doctor in New Hampshire name is Dr. Bennett who will prescribe this off label. Doubt anyone else will.

I take a dozen other supplements so I'm not able to tell what anyone of them is doing for me. I believe I am progressing slowly, though, but it may be due to just plain dumb luck, a robust nondrug regimen, i.e., exercises, etc. Who knows?

My email address is marcbanderson@gmail.com

Marc

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Marc,

Thanks for the information and help you have offered to this site. it is much appreciated. Also, Otolorin, thank you. You have always been a great help to this and all forums you participate in.

Thank you.

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Dear Pharmacist.

                              Thanks for your compliments and your support on this forum.

              

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