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Linda Garren    752

Hello, Dr. Binder.  I had seen and read that hypothesis, too, and found it so interesting that I sent it to my MDS.  He replied that 99% of the time, hypotheses are rejected.  What do you think (and may I ask what your doctorate is in?).  I would be very interested to get your thoughts on this.Thank you.

Linda

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Hi Linda:

I am a PhD. I realize that 99% of the time hypotheses are rejected, but I think this one might just be the 1% that cannot be. All I can say is that there is much to be said regarding a chronic infectious etiology for Parkinson's, the main question being which chronic infectious disease? The argument for this is clearly laid out in studies such as the recent review article What James Parkinson Really Thought was Behind Parkinson’s Disease which can be found at https://scientiaricerca.com/cons-articles.php  as well as studies like Anthony Fink's at UC Santa Cruz. Also in July, 2017 Emery et al came out with a study done at the University of Bristol in the UK which might seem unrelated since it deals with Alzheimer's but really is not. Often tissue samples of Alzheimer's disease mimic those found in Parkinson's, and clinically patients with Alzheimer's often share symptoms with those of Parkinson's. Emery's study showed a 5 to 10 fold increase in microbes in the Alzheimer's brain which are related to the same order and family (Actinomycetales; actinobacteria) that Berstad and Berstad recently subscribed to as the most likely cause of Parkinson's. By 1911, Alzheimer himself realized that one infectious process in the brain could manifest it as two different diseases, and there are those that feel that Parkinson's is a manifestation of the same disease process which merely concentrates its attack on the substantia nigra and surrounding tissue areas. There is an interesting video on the subject of chronic infectious disease and Parkinson's which you can view by going to https://vimeopro.com/user60766261/richard-melvin-an-artists-journey-into-parkinsons/video/203722203The Michael J. Fox Foundation has also in the past shown interest in research related to the mycobacteria in the Actinomycetales as well (https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=1310)  although I am not certain what the outcome of this trial was. Hope this sheds some light on the issue.

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