Jump to content
  • Announcements

    • ForumAdmin

      Frequently Asked Questions - Step by step guides

      Do you need assistance registering, logging in, posting, etc? Please visit the all new Frequently Asked Question Forum for step-by-step guides. Click the link below to access these helpful guides. Frequently Asked Questions
    • ForumAdmin

      Recursos Nuevos en Español

      http://www.parkinson.org/ayuda   http://www.parkinson.org/espanol    
    • ForumAdmin

      Línea de Ayuda 1-800-473-4636

      Línea de Ayuda 1-800-473-4636   ¿Qué es la línea de ayuda 1-800-4PD-INFO (473-4636) de la Fundación Nacional de Parkinson? Es un número de teléfono gratuito que ayuda a las personas con la enfermedad de Parkinson, sus familiares, amigos y profesionales de salud, a solucionar diferentes inquietudes.   La línea de ayuda ofrece: Información actualizada Apoyo emocional Referidos a profesionales de salud Recursos comunitarios Amplia variedad de publicaciones gratis    
Sign in to follow this  

Madopar dosage

Recommended Posts

Hi Dr Okun

I have recently commenced on Madopar in addition to the 1mg Azilect I take.  So far it works wonders and doesn't make me sick like pramipexole.  

The doc started me on 50/12.5 which kicks in reasonably quickly, around 20-30 minutes, and works for about 2 - 2.5 hours ( a bit variable in between).  Given he prescribed this dose 3 times per day, there is still a considerable amount of time it doesn't work.  He upped it to 100/25 morning and afternoon, with 50/12.5 in the middle of the day, but it still only lasts the 2 hours.  The doc has been happy for me to experiment a bit as long as I do it for a few days at a time to be sure about the result.

It is no big deal because I assume I can just take 50/12.5 more often, but I'm wondering, if 100/25 only works for as long as 50/12.5, then where does the excess go?  Is it typical that a higher dosage wouldn't work for longer than a smaller dose?

It also makes me wonder if I could get away with even less at 2.5 hour intervals.  I am only trying to treat the stiffness which from all of my reading is more of a dystonia type thing rather than rigidity.

Thanks again for your time.  Much more rare than a young person with PD is someone as generous with their time such as yourself.

Share this post

Link to post
Share on other sites

This is super important.  Interval can be as important as dose.  If you are just starting Madopar you may want to try higher dosages and move to closer intervals.  I usually work out the dose first and then the interval next.  Good luck with your doc.

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Sign in to follow this