Jump to content
  • Announcements

    • ForumAdmin

      Frequently Asked Questions - Step by step guides

      Do you need assistance registering, logging in, posting, etc? Please visit the all new Frequently Asked Question Forum for step-by-step guides. Click the link below to access these helpful guides. Frequently Asked Questions
    • ForumAdmin

      Recursos Nuevos en Español

      http://www.parkinson.org/ayuda   http://www.parkinson.org/espanol    
    • ForumAdmin

      Línea de Ayuda 1-800-473-4636

      Línea de Ayuda 1-800-473-4636   ¿Qué es la línea de ayuda 1-800-4PD-INFO (473-4636) de la Fundación Nacional de Parkinson? Es un número de teléfono gratuito que ayuda a las personas con la enfermedad de Parkinson, sus familiares, amigos y profesionales de salud, a solucionar diferentes inquietudes.   La línea de ayuda ofrece: Información actualizada Apoyo emocional Referidos a profesionales de salud Recursos comunitarios Amplia variedad de publicaciones gratis    

on off medication dosage

Recommended Posts



I am confronted with yopd/juvenile since 2001. overall it is going well.

the on/off is getting a pain.


can you give advice?

Madopar 50mg 7/day (all 1,5h)

Madopar 100 ret. 6:00 - 12:00 - 22:00

Requip 1mg 8/day

Azilect 1-0-0

zolpidem 0-0-1

Share this post

Link to post
Share on other sites


Could you please give me the specific times you take the Modopar 50mg? Also, is the Modopar 100mg a sustained released (Extended Release) or an immediate release tablet.

I would like this information so I may better give you a medication regime to help limit your "off" periods.

Thank You

Share this post

Link to post
Share on other sites

Madopar 100/25 immediate @ 6:00, 12:00, 22:00  (total 300mg)

Madopar T 50/12.5 mg @ 6:00, 7:30, 9:00, 10:30, 12:00, 13:30, 15:00, 16:30, 18:00, 19:30 (total 500mg)

Requip 1mg 6:00, 7:30, 10:30, 12:00, 13:30, 15:00 16:30, 18:00 (total 8mg)

Acilect 1mg 6:00

Zolipidem 10mg 23:00


as "stand-by"


Madopar LT


Looking forward to your help

Share this post

Link to post
Share on other sites


I have noticed some gaps in the Madopar which may be affecting the on/off periods. I also see some dosing of Madopar, which should be taken on an empty stomach, with other medications. With the great number of medications and times, i know it may be hard to avoid, but I tried to adjust. I will show you the new dosing chart after I explain why I made changes.

I first noticed that the all of the meds, except Ambien, are taken at 6:00am. Taking both Madopar's together may not be giving the coverage that might be needed. Also, since Madopar should be taken on an empty stomach, which I know can be difficult, I have moved the morning doses of Requip and Azilect to different times in the morning. I believe this move will also help with a longer coverage range. The last item I noticed is that Madopar 50/12.5 (which I will just call Madopar 50) last dose is given at 19:30 and the last dose of Madopar 100/12.5 (which I will just refer to as Madopar 100) is given at 22:00. This is a 2.5 hour difference, whereas the dosing during the day is only a 1.5 hour difference. I noticed that there is a 6 hour difference between Madopar 100 from 6:00 to 12:00 and a 10 hour difference between the 12:00 and 22:00. I have also assessed this difference of this and of the Madopar 50. I have also adjusted the Requip to alternate with the Madopar to alternate with the Madopar, since Madopar should be taken on an empty stomach.

I do know that everyone is different and that their medication dosing may also be different. I have tried to adjust the regime to maximize the on periods and minimize the off periods from a medical perspective.

Here is the new dosing schedule I have come up with:

Madopar 100: 6:00, 14:00, and 22:00

Madopar 50: 7:00, 8:30, 10:00, 11:30, 13:00, 14:30, 16:00, 17:30, 19:00, and 21:00

Requip: 6:30, 8:00, 9:30, 11:00, 12:30, 15:30, 17:00, and 18:30

Azilect: 6:30

Ambien: 23:00

When there needs to be a medication adjustment, it should only be done for one medication at a time, unless one of the medications is only being taken once a day and the shange is less than 6 hours. Since the changes in times are very small, you could make the change in that medication without tapering it. This is the order in which I would change them and for how long before changing the next medication.

1) Change the Madopar 100 times first. It can be started immediately.

2) The second and third medications to change should be the Requip and Azilect These should be started 1 week after changing the Madopar 100.

3) The last medication to change should be Madopar 50. This should be started 1 week after the Requip and Azilect change.

4) The Ambien should remain the same.

I hope this helps and please keep me posted



Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now