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Gene

Interactions

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My hallucinations are getting out of hand. I've been Nuplazid 34mg daily since Dec, it help control them since mid-March. Is there an interaction if I suggest to Nuero  to add quetiapine to go along with the Nuplazid. I started Rytary in March, still trying to adjust dose. Right now, I'm taking 2 145mg caps 4 times a day8-1-6-11. Thanks for any insight.

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Gene,

There are 2 moderate interactions:

1) Levodopa (Rytary) & Quetiapine: Quetiapine has central antidopaminergic activity and may antagonize the effects of Levodopa, which is a Dopaminergic Agonist. It should be avoided if at all possible.

2) Quetiapine & Nuplazid: The concern is that Quetiapine may have an additive cardiovascular effects in combo with other meds that are known to prolong the QT interval of an electrocardiogram. Coadministration of Quetiapine and other meds that can cause a prolonged QT interval should be avoided is at all possible.

I am sure your physician is aware of these to moderate interactions and will take them into consideration if he decides to use Quetiapine.

I hope this helps and please keep me posted

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