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Madopar vs Madopar HBS

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Hi Mark

I've never posted a question in this section so thank you very much for your opinion.  I also posted this question to Dr Okun but I thought I might pick your brain also if that is ok. 

I have been taking regular Madopar 50/12.5 around 5 to 7 times per day.  I was just waiting until it wore off and then took another.  When it wears off I feel stiff and have difficulty walking normally, and also get fuzzy in my mind.  I tried 100/25 regular but it gives me a headache and makes me feel tired, and doesn't last any longer.

My neuro swapped me to Madopar HBS 100/25 and it lasts much longer.  Three a day along with the Azilect I already take is enough to keep me moving properly all day.  The downside is that it gives me a constant mild headache and makes me feel a bit sick/tired/groggy.  

Although I move better over the day on the HBS, I felt way less sick taking the 5-7 regular Madopar.  I had a similar negative effect when I used to take pramipexole.  I have only been taking the HBS for a few days but is this side effect common and likely to improve?


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The headache is very common and does usually go away over time, usually about a month. If after that time frame your headache does not go away, I would probably switch back to the Madopar 50/12.5 5 to 7 tablets per day.

I have had some people find relief of the headaches by taking Excedrin. Don't take is you take blood thinners because Excedrin does contain Aspirin, as well as Acetaminophen (Tylenol), and caffeine. It appears like this combination really woks well. If the headaches do continue after about a week, you can take the Excedrin with the Madopar.

I hope this helps and please keep me posted.

I hope th

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