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Dr. Okun

PDTRIALS UPDATE

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Dear Forum members here is an update from our friends at PDtrials:

 

PDtrials is a collaborative initiative of Parkinson's organizations and is dedicated

to increasing awareness and education about Parkinson's clinical trials. Please

contact us [info@pdtrials.org] if you would like more information about this

effort.

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New Clinical Trials

 

 

 

Using Heavy Water to Study Cell Dynamics in Parkinson's Disease

This pilot study, enrolling a total of 30 participants, will assess the feasibility

of using heavy water as a safe 'tracer' for biomarker studies of diseases of the

brain and spinal cord, that, together, are also called the central nervous system.

Heavy water is the same as normal drinking water except the hydrogen atoms have

been replaced by deuterium, a naturally occurring isotope of hydrogen. If this method

can be used to establish the rates of immune cell turnover and the production rates

of neuronal molecules using cerebrospinal fluid, it will provide unique data that

is important to understand chronic neurodegenerative conditions, like PD, and to

measure responses to targeted therapies.

Learn more: http://www.pdtrials.org/en/browse/all/view/267

 

A Study of Folic Acid and L-Methylfolate in Parkinson's Disease

This study is being conducted to assess the impact of folate and L-methylfolate

on the progression of PD. The investigators are specifically looking for the effect

of these nutritional supplements in people with Parkinson's who have an antibody

that effects their body's utilization of folate. Folate is an important vitamin

that takes part in many critical cell functions so an antibody that prevented it

from entering the brain properly could cause or worsen certain neurological disorders

like Parkinson's. The investigators will also be looking at the blood of some individuals

who do not have Parkinson's, and will be enrolling a total of 260 participants.

Learn more: http://www.pdtrials.org/en/browse/all/view/262

 

Medication Plus Psychotherapy for Anxiety, Worry or Stress in Older Adults, Including

Those with Parkinson's

Almost one in ten older Americans experiences worry or anxiety that interferes with

day-to-day activities or getting to sleep. These problems are more common than depression,

Alzheimer's disease, or other dementias in older adults. This study examines whether

adding a type of psychotherapy called cognitive behavioral therapy to the antidepressant

medication escitalopram (Lexapro) can help older adults with Generalized Anxiety

Disorder (GAD) get better and stay well. People with PD may be eligible for this

study, which is enrolling 60 participants, along with their caregivers and other

people who do not have PD.

Learn more: http://www.pdtrials.org/en/browse/all/view/266

 

 

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Gaucher Disease Linked to Parkinson's

 

People who carry the gene for a rare genetic problem known as Gaucher disease have

at least five times the normal risk of developing PD, researchers reported today

in the New England Journal of Medicine. Some clinicians had noticed an apparent

link between the two conditions in the past, but a new international study of nearly

5,700 people is the first to show the magnitude of the risk. The finding suggests

that the gene is one cause of the disease, but indicates that other factors must

be operating as well because not all patients who have Gaucher also develop Parkinson's.

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1256222315

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Forty People with Parkinson's Graduate from PDF's Research Advocacy Training Program

 

Last week, more than forty people living with PD from across the US participated

in the Parkinson's Disease Foundation's (PDF) Second Clinical Research Learning

Institute. Held in Florham Park, New Jersey, the novel three-day program prepares

participants to be part of the clinical research process - the stage of treatment

development that brings new, and much-needed, therapies for Parkinson's from "bench

to bedside."

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1256222253

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Body's Own Antioxidant May Slow Parkinson's Decline, Study Says

 

Researchers Higher concentrations of a natural antioxidant in the body may slow

the progression of PD in patients with early stages of the illness, a study from

Harvard researchers found. Those in the study with the highest amounts of antioxidant

urate in their blood were 36 percent less likely to need treatment within two years

for early Parkinson's symptoms than those with the lowest levels, research online

today in the Archives of Neurology showed.

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1255532122

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Gene Therapy Shows Promise for Parkinson's

 

For Macaque monkeys that received gene therapy for symptoms of PD saw a significant

improvement in their motor function without the side effects associated with current

standard therapy, researchers say. Simultaneous insertion of three genes allowed

certain cells in the brain to take over production of the neurotransmitter dopamine.

Too-low levels of dopamine cause the hallmark motor-control symptoms of Parkinson's.

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1256046932

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Door Opens to Health Claims Tied to Agent Orange

 

Under rules to be proposed this week, the Department of Veterans Affairs plans to

add PD, ischemic heart disease and hairy-cell leukemia to the growing list of illnesses

presumed to have been caused by Agent Orange, the toxic defoliant used widely in

Vietnam.

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1256046815

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Using Music to Ease Patient Stress During Surgery

 

For as long as humans have pounded drums and plucked strings, listening to music

has affected people's sense of well-being, lifting their spirits and - as new research

shows - calming their nerves. Literally. According to a study at Cleveland Clinic,

music can slow the neuronal firings deep within the brain during surgery designed

to treat Parkinson's patients.

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1256047112

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Drivers With Parkinson's Disease At Higher Risk Of Crashes In Low Visibility

 

Drivers with mild to moderate PD may be at higher risk of crashes on foggy days

and other times of low visibility. The research, involving a driving simulation

test, is published in the October 6, 2009, print issue of Neurology, the medical

journal of the American Academy of Neurology. In addition to affecting movement,

PD affects visual skills, such as the ability to see contrast, and the speed of

processing what is seen.

 

Read on: http://www.pdtrials.org/en/clinical_res ... 1254837983

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Have You Participated in a Parkinson's Clinical Study? Join the Partners in Progress

Honor Roll Today!

 

If you have participated in a Parkinson's clinical study, we'd like to recognize

your very personal commitment to help move Parkinson's clinical research forward

by providing you with a PDtrials baseball cap as a token of our thanks and adding

you to our Partners in Progress Honor Roll. Take a look at our Honor Roll of participants

here: http://www.pdtrials.org/en/partners_in_progress

and if you would like to be included, contact us [mailto] today!

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PDtrials is Now on Facebook...Join our Network Today!

 

PDtrials has launched a page on Facebook -- the world's most widely-used social

networking website. Visit our new page to preview events hosted by PDtrials and

our partners, view photos of our Partners in Progress Honor Roll, and join discussions

about clinical research for Parkinson's. Visit us on Facebook and become a Fan!

 

In This Issue

 

New Clinical Trials

Gaucher Disease Linked to Parkinson's

40 People with Parkinson's Graduate from PDF's Research Advocacy Training

Program

Body's Own Antioxidant May Slow Parkinson's Decline, Study Says

Gene Therapy Shows Promise for Parkinson's

Door Opens to Health Claims Tied to Agent Orange

Using Music to Ease Patient Stress During Surgery

Drivers With Parkinson's Disease At Higher Risk Of Crashes In Low Visibility

 

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PDtrials is led by

 

Parkinson's Disease

 

In collaboration with:

APDA

FOX

National Parkinson Foundation

Parkinson's Action Network

Parkinson Alliance

We Move

 

PDtrials is advised by:

National Institutes Of Health

The Parkinson's Institute

Parkinson Pipeline Project

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© 2009 PDtrials. All Rights Reserved.

 

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