It absolutely makes sense. Dopamine is the main chemical which makes muscle move. When we lack Dopamine, we lack the muscle motor skills, and we then have PD. When we work out, exercise, or do anything strenuous our body requires us to use more muscle strength, which requires more Dopamine. That is why if you have PD and do not take your medication before you do some sort of work out, you will definitely be off afterwards.
I always recommend that PD patients do any exercise son after they take their PD medication. That way they will not be off ahterwards.
I hope this helps and please keep me posted.